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EFFECTS OF SEPSIS ON NERVE EVOKED RESPONSES

Novak, Kevin Richard
http://rave.ohiolink.edu/etdc/view?acc_num=wright1216123137

Abstract Details

2008, Master of Science (MS), Wright State University, Anatomy.
Sepsis and SIRS (systemic inflammatory response syndrome) have become two expensive and complicated problems seen in the intensive care unit (ICU). These two illnesses have been known to cause dysfunction with excitable tissues in the body. Encephalopathy, neuropathy, and myopathy are the three biggest. In this paper we discuss the development of an animal model of sepsis and the neurological complications sepsis brought about. Nerve conduction studies showed increased durations on compound muscle action potential, and decreased amplitude as well as increased duration and latency on sensory nerve action potentials. These results were not consistent with the two most common neuropathies, demyelinating and axonal. Collaborative efforts with the Cope lab found that action potential amplitudes of individual axons could be improved by delivering a hyperpolarizing current. This data is supported by similar findings in muscle fibers by the Rich lab.
Mark Rich, M.D. (Advisor)
Timothy Cope, PhD. (Committee Member)
John Pearson, PhD. (Committee Member)
Joseph F. Thomas, Jr., PhD. (Other)
34 p.
Neurology
sepsis; nerve conductions; CMAP; SNAP; compound muscle action potential; sensory nerve action potential;

Recommended Citations

Citations

  • Novak, K. R. (2008). EFFECTS OF SEPSIS ON NERVE EVOKED RESPONSES [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1216123137

    APA Style (7th edition)

  • Novak, Kevin. EFFECTS OF SEPSIS ON NERVE EVOKED RESPONSES. 2008. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1216123137.

    MLA Style (8th edition)

  • Novak, Kevin. "EFFECTS OF SEPSIS ON NERVE EVOKED RESPONSES." Master's thesis, Wright State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1216123137

    Chicago Manual of Style (17th edition)

wright1216123137
546
© 2008, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.