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Reorganization of Ia afferent synapses on motoneurons after peripheral nerve injuries

Titus, Haley E.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1245378110

Abstract Details

2009, Master of Science (MS), Wright State University, Anatomy.
After peripheral nerve injuries patients lose and do not recover the stretch reflex which leads to altered locomotor function. The focus of this thesis is to investigate the structural integrity of the central connection between Ia afferents and alpha motoneurons that mediate the stretch reflex. The overall hypothesis is that the density and distribution of Ia synapses on motoneurons is altered after peripheral nerve injuries. Analysis of Ia afferent-motoneuron contacts, revealed by vesicular glutamate transporter 1 (VGLUT1) immunoreactivity, on the soma and dendritic arbor of motoneurons after peripheral nerve injuries revealed major reorganizations in the distribution and density of Ia synapses. Synaptic stripping of Ia afferent synapses occurred on the soma and proximal dendrites and appeared to be permanent even after reinnervation; in contrast, VGLUT1 synapses on distal dendrites were unchanged. In conclusion, after peripheral nerve injuries motoneurons are contacted by fewer Ia synapses and they are more distally located. This overall reorganization likely weakens the input and may contribute to stretch reflex anomalies.
Francisco J. Alvarez, PhD (Advisor)
Timothy Cope, PhD (Committee Member)
Mark Rich, PhD (Committee Member)
95 p.
Biomedical Research; Neurology
Ia afferent; motoneuron; dendrite; VGLUT1; stretch reflex; synaptic stripping

Recommended Citations

Citations

  • Titus, H. E. (2009). Reorganization of Ia afferent synapses on motoneurons after peripheral nerve injuries [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1245378110

    APA Style (7th edition)

  • Titus, Haley. Reorganization of Ia afferent synapses on motoneurons after peripheral nerve injuries. 2009. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1245378110.

    MLA Style (8th edition)

  • Titus, Haley. "Reorganization of Ia afferent synapses on motoneurons after peripheral nerve injuries." Master's thesis, Wright State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1245378110

    Chicago Manual of Style (17th edition)

wright1245378110
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© 2009, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.