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wright1245878489.pdf (1.69 MB)
ETD Abstract Container
Abstract Header
Host Defense Mechanisms Against Mycobacterium Tuberculosis
Author Info
Holloway, Laurin Nicole
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=wright1245878489
Abstract Details
Year and Degree
2009, Master of Science (MS), Wright State University, Microbiology and Immunology.
Abstract
Mycobacterium tuberculosis is one of the world’s most infectious diseases. Approximately 2 million people die each year from Mycobacterium tuberculosis infection and one-third of the world’s population remains infected. For decades research has focused on uncovering the tactics used by Mycobacterium tuberculosis to evade host immune responses and defense mechanisms used to fight tuberculosis infection. The following review focuses on the host defense mechanisms used to combat Mycobacterium tuberculosis with an emphasis placed on the roles that Toll-like receptors (TLRs), T cells (gamma delta, CD4, CD8), and macrophages play in mounting the innate and adaptive immune responses necessary to eradicate this disease. The challenges of designing an effective vaccine to fight Mycobacterium tuberculosis infection and the two first-line anti-tuberculosis inhalant drugs, Isoniazid (H) and Rifampicin (R) are also discussed.
Committee
Nancy Bigley, PhD (Advisor)
Barbara Hull, PhD (Committee Member)
Courtney Sulentic, PhD (Committee Member)
Pages
110 p.
Subject Headings
Immunology
;
Microbiology
Keywords
Mycobacterium tuberculosis
;
host defense mechanisms
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Citations
Holloway, L. N. (2009).
Host Defense Mechanisms Against Mycobacterium Tuberculosis
[Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1245878489
APA Style (7th edition)
Holloway, Laurin.
Host Defense Mechanisms Against Mycobacterium Tuberculosis.
2009. Wright State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=wright1245878489.
MLA Style (8th edition)
Holloway, Laurin. "Host Defense Mechanisms Against Mycobacterium Tuberculosis." Master's thesis, Wright State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1245878489
Chicago Manual of Style (17th edition)
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Document number:
wright1245878489
Download Count:
1,801
Copyright Info
© 2009, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.