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A POTENTIAL STRATEGY TO MAINTAIN HSV-1 IN A LATENT STATE: USE OF IMMUNOREGULATORY PEPTIDE MIMETICS

Majidi, Nasrin

Abstract Details

2009, Master of Science (MS), Wright State University, Biological Sciences.

Majidi, Nasrin. M.S., Department of Biological Sciences, Microbiology and Immunology Program, Wright State University, 2009. A potential strategy to maintain HSV-1 in a latent state: use of immunoregulatory peptide mimetics.

This study reviews the role of interferon-gamma (IFN-gamma) in HSV-1 latency. CD8+ T cells inhibit the reactivation of HSV-1 in trigeminal ganglia (TG) by production of IFN-gamma. Although CD8+ T cells include all the cytotoxic apparatus for cytotoxicity, latently infected neuronal cells are not killed by CD8+ T cells. The CD94-NKG2a molecule on CD8+ T cells, binds to Qa-1b (a MHC class I like molecule) present on neuronal cell to inhibit CD8+ T cells cytotoxicity. Other studies have also determined that the IFN-gamma peptide mimetic 95-132 inhibits HSV-1 replication in the same way as IFN-gamma in infected cells. IFN-gamma mimetic peptide binds to intracellular domain of interferon gamma receptor-1(IFNGR-1) and initiates IFN-gamma signal transduction to the nucleus for gene activation. IFN-gamma mimetic also is more active than IFN-gamma in gamma activated sequences (GAS) promoter. Epithelial cells such as keratinocytes are the major target cell for HSV-1 replication. In a murine keratinocyte cell line (HEL-30), suppressor of cytokine signaling-1 (SOCS-1) prevents the antiviral activity of IFN-gamma by inhibition of the JAK/STAT signaling pathway.

Nancy J. Bigley, PhD (Committee Chair)
Nancy J. Bigley, PhD (Committee Member)
Barbara E. Hull, PhD (Committee Member)
Cheryl L. Conley, PhD (Committee Member)
Joseph F. Thomas Jr., PhD (Other)
50 p.

Recommended Citations

Citations

  • Majidi, N. (2009). A POTENTIAL STRATEGY TO MAINTAIN HSV-1 IN A LATENT STATE: USE OF IMMUNOREGULATORY PEPTIDE MIMETICS [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1260921490

    APA Style (7th edition)

  • Majidi, Nasrin. A POTENTIAL STRATEGY TO MAINTAIN HSV-1 IN A LATENT STATE: USE OF IMMUNOREGULATORY PEPTIDE MIMETICS. 2009. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1260921490.

    MLA Style (8th edition)

  • Majidi, Nasrin. "A POTENTIAL STRATEGY TO MAINTAIN HSV-1 IN A LATENT STATE: USE OF IMMUNOREGULATORY PEPTIDE MIMETICS." Master's thesis, Wright State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1260921490

    Chicago Manual of Style (17th edition)