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Developmental Expression of Calcium Buffering Proteins in Central Auditory Pathways of Normal Hearing and Congenitally Deaf Mice

Deardorff, Adam S.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1276870379

Abstract Details

2010, Master of Science (MS), Wright State University, Anatomy.
These experiments analyze differences in synaptic development in central auditory pathways between normal hearing (CBA/J) and congenitally deaf (dn/dn) mice, which provide valuable insight into central synaptic plasticity corresponding to human congenital deafness. Immunofluorescent analysis of the developmental expression of the calcium buffering proteins calretinin, calbindin d-28k, and parvalbumin at various postnatal time points was performed to assess the effects of altered neural activity on the level and/or pattern of protein expression within these nuclei. Results indicate that the pattern of calbindin and parvalbumin is unaffected by congenital deafness in dn/dn mice. However, the pattern of calretinin expression in the MNTB during development of dn/dn mice differed significantly from that of CBA/J mice, indicating that calcium buffering may be impaired in these synapses without appropriate afferent stimulation.
Robert E.W. Fyffe, Ph.D. (Advisor)
Larry J. Ream, Ph.D. (Committee Member)
John C. Pearson, Ph.D. (Committee Member)
320 p.
Biomedical Research; Neurology
Auditory Pathways; Calcium Buffering Proteins; Calretinin; Calbindin; Parvalbumin; Congenital Deafness; Synaptic Development; dn/dn mice

Recommended Citations

Citations

  • Deardorff, A. S. (2010). Developmental Expression of Calcium Buffering Proteins in Central Auditory Pathways of Normal Hearing and Congenitally Deaf Mice [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1276870379

    APA Style (7th edition)

  • Deardorff, Adam. Developmental Expression of Calcium Buffering Proteins in Central Auditory Pathways of Normal Hearing and Congenitally Deaf Mice. 2010. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1276870379.

    MLA Style (8th edition)

  • Deardorff, Adam. "Developmental Expression of Calcium Buffering Proteins in Central Auditory Pathways of Normal Hearing and Congenitally Deaf Mice." Master's thesis, Wright State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1276870379

    Chicago Manual of Style (17th edition)

wright1276870379
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This open access ETD is published by Wright State University and OhioLINK.