Skip to Main Content
 

Global Search Box

 
 
 
 

ETD Abstract Container

Abstract Header

Short-Term Administration of Corticosterone has Lasting Effects on Learning in Young Rats

Wentworth-Eidsaune, Christine L.

Abstract Details

2010, Master of Science (MS), Wright State University, Anatomy.
Corticosterone is a glucocorticoid released as part of the body's response to stress and is known to affect cognitive function, presumably via effects on the hippocampus. Trace classical eyeblink conditioning depends on the hippocampus, and has been used to examine the development of learning processes in young organisms. Experiment 1 was a dosing study, in which time course of effect of corticosterone was followed in 15-day-old Long-Evans rat pups over 24 hours for 4 different concentrations (high: 0.02 mg/g body weight (b.w.), medium: 0.01mg/g b.w., low: 0.005 mg/g b.w. and a vehicle control). In Experiment 2, two subcutaneous injections (0.02 mg/g b.w., 0.005 mg/g b.w., or vehicle control) were administered over a 3-day period, starting at PND 15. Ten days after injections, animals underwent trace classical eyeblink conditioning to examine the possible lasting effects of the elevated corticosterone levels on learning and memory. Eyeblink conditioning was affected by corticosterone treatments, but only for males, and only very early in acquisition. Males receiving the high dose of corticosterone exhibited facilitation of learning relative to controls.
Dragana Claflin, PhD (Advisor)
Larry Ream, PhD (Advisor)
Michael Hennessy, PhD (Committee Member)
John Pearson, PhD (Committee Member)
39 p.

Recommended Citations

Citations

  • Wentworth-Eidsaune, C. L. (2010). Short-Term Administration of Corticosterone has Lasting Effects on Learning in Young Rats [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1277133963

    APA Style (7th edition)

  • Wentworth-Eidsaune, Christine. Short-Term Administration of Corticosterone has Lasting Effects on Learning in Young Rats. 2010. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1277133963.

    MLA Style (8th edition)

  • Wentworth-Eidsaune, Christine. "Short-Term Administration of Corticosterone has Lasting Effects on Learning in Young Rats." Master's thesis, Wright State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1277133963

    Chicago Manual of Style (17th edition)