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Hyperbaric Oxygen in the Prevention of Carbon Monoxide Induced Delayed Neurological Sequelae in Male Sprague Dawley Rats (Rattus norvegicus)

Gut, Chester P., Jr.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1278639454

Abstract Details

2010, Master of Science (MS), Wright State University, Pharmacology and Toxicology.
In Carbon Monoxide (CO) induced Delayed Neurological Sequelae (DNS) clinical signs develop 1 to 6 weeks after CO has cleared the body. The aim of this experiment was to develop a model of CO induced DNS which closely mimics “real world” conditions both in exposure and treatment. The model was challenged with hyperbaric or normobaric oxygen, or room air. Basic behaviors were measured by Open Field test on days 1, 7, 14 post exposure and treatment. No significant difference in behavior was observed between exposed and control animals or between treatment groups. Histological analyses showed no DNA or necrotic damage to the basal ganglia, cortex, or hippocampus in CO exposed animals at time of euthanasia regardless of treatment. Data suggest variability in tolerance to CO and development of DNS. Data also indicates that the in vivo COHb half-life is not constant across species.
Richard Simman, MD (Committee Chair)
Marianna Morris, PhD (Committee Co-Chair)
James Lucot, PhD (Committee Member)
Khalid Elased, PhD (Committee Member)
78 p.
Toxicology
Carbon Monoxide; Hyperbaric Oxygen; Neurological Sequelae; carboxyhemoglobin half-life; rat;

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Citations

  • Gut, Jr., C. P. (2010). Hyperbaric Oxygen in the Prevention of Carbon Monoxide Induced Delayed Neurological Sequelae in Male Sprague Dawley Rats (Rattus norvegicus) [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1278639454

    APA Style (7th edition)

  • Gut, Jr., Chester. Hyperbaric Oxygen in the Prevention of Carbon Monoxide Induced Delayed Neurological Sequelae in Male Sprague Dawley Rats (Rattus norvegicus). 2010. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1278639454.

    MLA Style (8th edition)

  • Gut, Jr., Chester. "Hyperbaric Oxygen in the Prevention of Carbon Monoxide Induced Delayed Neurological Sequelae in Male Sprague Dawley Rats (Rattus norvegicus)." Master's thesis, Wright State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1278639454

    Chicago Manual of Style (17th edition)

wright1278639454
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© 2010, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.