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Persisiting Sensitization of Depressive-Like Behavior and Thermogenic Response During Maternal Separation in Pre- and Post Weaning Guinea Pigs

Schneider, Randi Lynn

Abstract Details

2011, Master of Science (MS), Wright State University, Anatomy.
Early attachment disruption is thought to promote later onset of depressive illness through a process involving sensitization. Maternal separation in guinea pig pups (~21 days of age) produces depressive-like behavior and core body temperature fluctuations that appear to be mediated by proinflammatory activity. These responses are enhanced during repeated separations over several days. Here, enhanced depressive-like behavior and core body temperature responses were observed from the early pre-weaning to the periadolescent period (~10-40 days of age) and persisted for more than a week. The greatest temperature response was observed during the final separation. These results demonstrate persisting sensitization of behavioral and thermogenic responses to maternal separation over the age range in which these responses are known to occur. Further, the findings are consistent with the hypothesis that proinflammatory activity contributes to the sensitization response and suggest that the impact of early attachment disruption on susceptibility to depression involves proinflammatory processes.
Michael Hennessy, PhD (Advisor)
Timothy Cope, PhD (Other)
Patricia Schiml, PhD (Committee Member)
John Pearson, PhD (Committee Member)
Andrew Hsu, PhD (Other)
31 p.

Recommended Citations

Citations

  • Schneider, R. L. (2011). Persisiting Sensitization of Depressive-Like Behavior and Thermogenic Response During Maternal Separation in Pre- and Post Weaning Guinea Pigs [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1309794651

    APA Style (7th edition)

  • Schneider, Randi. Persisiting Sensitization of Depressive-Like Behavior and Thermogenic Response During Maternal Separation in Pre- and Post Weaning Guinea Pigs. 2011. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1309794651.

    MLA Style (8th edition)

  • Schneider, Randi. "Persisiting Sensitization of Depressive-Like Behavior and Thermogenic Response During Maternal Separation in Pre- and Post Weaning Guinea Pigs." Master's thesis, Wright State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1309794651

    Chicago Manual of Style (17th edition)