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Modifiable Hyperbranched Polyester Drug Delivery Systems

Ogden, Dorothy
http://rave.ohiolink.edu/etdc/view?acc_num=wright1316178520

Abstract Details

2011, Master of Science (MS), Wright State University, Chemistry.
This work encompassed synthesis and characterization of biocompatible hyperbranched polyester drug delivery systems prepared with fumaric acid, glycerol and polyethylene glycol. The polymers were manufactured in the melt utilizing A2 + CB2 polymerization. The ratio of A2:CB2 was modified and excess B was added to end-cap the polymers to avoid cross-linking. Fumaric acid was selected as the A2 monomer because the double bond provided a site for polymer backbone modification or covalent attachment of active pharmaceutical ingredients. Acetaminophen and Ondansetron Hydrochloride were added to evaluate feasibility of using the polyesters as drug delivery systems. The weight average molecular weight of the A2 + CB2 polymer systems with the end-capping agent ranged from 5100 to 8500 Da with PDI values between 1.3 and 1.7. The polymers containing Acetaminophen appeared to degrade while the polymers with Ondansetron were determined to be immediate-release dosage forms.
Eric Fossum, PhD (Committee Chair)
William Feld, PhD (Committee Member)
Kenneth Turnbull, PhD (Committee Member)
59 p.
Chemistry; Organic Chemistry; Polymer Chemistry
A2 + CB2 polymerization; end-capped polymers

Recommended Citations

Citations

  • Ogden, D. (2011). Modifiable Hyperbranched Polyester Drug Delivery Systems [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1316178520

    APA Style (7th edition)

  • Ogden, Dorothy. Modifiable Hyperbranched Polyester Drug Delivery Systems. 2011. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1316178520.

    MLA Style (8th edition)

  • Ogden, Dorothy. "Modifiable Hyperbranched Polyester Drug Delivery Systems." Master's thesis, Wright State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1316178520

    Chicago Manual of Style (17th edition)

wright1316178520
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© 2011, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.