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FRIEDEL-CRAFTS ACYLATION STUDIES ON 3-ALKYL-1-(PHENYLSULFONYL)INDOLES USING ALUMINUM CHLORIDE AND BISMUTH TRIFLATE

Karrepu, Venkateswara Reddy
http://rave.ohiolink.edu/etdc/view?acc_num=wright1333733182

Abstract Details

2012, Master of Science (MS), Wright State University, Chemistry.
Using the traditional catalyst, aluminum chloride in stoichiometric amounts, 3-alkyl-1-(phenylsulfonyl)indoles can be regioselectively acylated under Friedel-Crafts conditions at the C-6 position along with 10% of a minor isomer at the C-5 position. Alternatively, using catalytic amounts of the green catalyst, bismuth triflate, C-2 acylation was observed. Therefore, regioselectivity can be controlled by the nature of the Lewis acid catalyst. Moreover, this is the first-time that Friedel-Crafts acylation studies were demonstrated upon 3-alkyl-1-(phenylsulfonyl)indoles.
Daniel Ketcha, PhD (Advisor)
Eric Fossum, PhD (Committee Member)
Vladimir Katovic, PhD (Committee Member)
82 p.
Chemistry
Friedel-Crafts Acylation; 3-Alkyl-1-(Phenylsulfonyl)indoles; aluminum chloride; bismuth triflate

Recommended Citations

Citations

  • Karrepu, V. R. (2012). FRIEDEL-CRAFTS ACYLATION STUDIES ON 3-ALKYL-1-(PHENYLSULFONYL)INDOLES USING ALUMINUM CHLORIDE AND BISMUTH TRIFLATE [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1333733182

    APA Style (7th edition)

  • Karrepu, Venkateswara Reddy. FRIEDEL-CRAFTS ACYLATION STUDIES ON 3-ALKYL-1-(PHENYLSULFONYL)INDOLES USING ALUMINUM CHLORIDE AND BISMUTH TRIFLATE. 2012. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1333733182.

    MLA Style (8th edition)

  • Karrepu, Venkateswara Reddy. "FRIEDEL-CRAFTS ACYLATION STUDIES ON 3-ALKYL-1-(PHENYLSULFONYL)INDOLES USING ALUMINUM CHLORIDE AND BISMUTH TRIFLATE." Master's thesis, Wright State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1333733182

    Chicago Manual of Style (17th edition)

wright1333733182
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© 2012, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.