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MATURATION OF THE CAROTID BODY OXYGEN-SENSOR DURING RAT DEVELOPMENT

Paulet, Julia
http://rave.ohiolink.edu/etdc/view?acc_num=wright1337703804

Abstract Details

2012, Master of Science (MS), Wright State University, Anatomy.
Carotid bodies (CB) are paired, oxygen-sensing organs located in the bifurcation of the carotid artery that act as peripheral chemoreceptors in the detection of hypoxic, hypercapnic and acidotic levels in the arterial blood. CBs respond to these fluctuations in blood gases by initiating firing of the carotid sinus nerve. This ultimately results in the appropriate ventilatory change to restore blood gases to their physiological levels. Studies have shown that the hypoxic response of the carotid body in juvenile mammals is low, but as maturation occurs this response is strengthened and clearly exhibited in adults. One theory suggests mitochondria play a vital role in the oxygen sensitivity of Type I cells in carotid bodies. The experimental hypothesis of this project is that mitochondria in the oxygen sensing Type I cells of rat carotid bodies change in number and /or distribution during the development of the acute hypoxic ventilatory response. Type I cells were isolated from juvenile (4-6 days) and mature (14-16 days) rat carotid bodies and loaded with mitotracker to quantify mitochondrial content. Data obtained demonstrated a significant reduction in the total volume of mitochondria in Type I cells during development which was not paralleled by a fall in metabolic rate, indicating an increase in the rate of mitochondrial oxidative phosphorylation. These findings suggest that change in mitochondrial content during the development of the hypoxic response might be crucial for this mechanism's development.
Christopher Wyatt, PhD (Advisor)
Robert Putnam, PhD (Committee Member)
James Olson, PhD (Committee Member)
Timothy Cope, PhD (Other)
Andrew Hsu, PhD (Other)
90 p.
Anatomy and Physiology
anatomy; physiology

Recommended Citations

Citations

  • Paulet, J. (2012). MATURATION OF THE CAROTID BODY OXYGEN-SENSOR DURING RAT DEVELOPMENT [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1337703804

    APA Style (7th edition)

  • Paulet, Julia. MATURATION OF THE CAROTID BODY OXYGEN-SENSOR DURING RAT DEVELOPMENT. 2012. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1337703804.

    MLA Style (8th edition)

  • Paulet, Julia. "MATURATION OF THE CAROTID BODY OXYGEN-SENSOR DURING RAT DEVELOPMENT." Master's thesis, Wright State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1337703804

    Chicago Manual of Style (17th edition)

wright1337703804
573
© 2012, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.