Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


wright1341957043.pdf (3.01 MB)

ETD Abstract Container

Abstract Header

Comparing Two Different Statins in a Delayed Pharmacological Treatment for Ischemic Stroke

Hagerty, Kailyn M.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1341957043

Abstract Details

2012, Master of Science (MS), Wright State University, Physiology and Neuroscience.
Stroke is one of the leading causes of death and the top cause of long term disability. Currently there exists no standardized treatment of care for ischemic stroke patients during the days following stroke other than giving aspirin. A drug combination containing fluoxetine, one of two statins, and ascorbic acid was used to try and improve motor function following strokes in rats. Endothelin induced stroke survival surgery was performed on the right cortex of Long Evans and Sprague Dawley rats. Functional tests were completed pre- and post-surgery and immunohistochemistry was carried out to analyze infarct volume, angiogenesis, and the glial scar. Significant recovery of function was seen after treatment with fluoxetine, simvastatin, and ascorbic acid. Strong trends indicating increased angiogenesis and reduced infarct volume following treatment with fluoxetine, atorvastatin, and ascorbic acid. The glial scar was significantly reduced in animals treated with the atorvastatin combination. Increases in angiogenesis and neurogenesis caused by pharmacological treatment could be helpful in reducing the lifelong implications of stroke.
Adrian Corbett, PhD (Advisor)
Robert Putnam, PhD (Committee Member)
Kathrin Engisch, PhD (Committee Member)
78 p.
Neurosciences
ischemic stroke; rats; fluoxetine; angiogenesis; glial scar

Recommended Citations

Citations

  • Hagerty, K. M. (2012). Comparing Two Different Statins in a Delayed Pharmacological Treatment for Ischemic Stroke [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1341957043

    APA Style (7th edition)

  • Hagerty, Kailyn. Comparing Two Different Statins in a Delayed Pharmacological Treatment for Ischemic Stroke. 2012. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1341957043.

    MLA Style (8th edition)

  • Hagerty, Kailyn. "Comparing Two Different Statins in a Delayed Pharmacological Treatment for Ischemic Stroke." Master's thesis, Wright State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1341957043

    Chicago Manual of Style (17th edition)

wright1341957043
764
© 2012, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.