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House Dust Mite Induced Gene Expression and Cytokine Secretion by Human Dermal Fibroblasts

Rockwood, Jananie

Abstract Details

2012, Master of Science (MS), Wright State University, Biological Sciences.
House dust mites are a group of mites that are commonly found in homes worldwide. The three most commonly found species of house dust mites in temperate environments in the United States are Dermatophagoides farinae, Dermatophagoides pteronyssinus and Euroglyphus maynei. House dust mite allergens are strongly associated with asthma, perennial rhinitis and atopic dermatitis. Whole dust mite extracts contain both allergen and non-allergen molecules that can influence cell functions in the skin, mucous membranes of the nose and eyes, and epithelial linings of the lungs. Extracts from the three different house dust mite species contain different molecules that induce different responses. The purpose of this study was to investigate how molecules in house dust mite extracts modulate IL-6, IL-8, MCP-1 and M-CSF cytokine gene expression and secretion by normal human dermal fibroblast (NHDF) cells. This study demonstrated that in some instances cytokine gene expression and secretion were induced while in other instances only stored cytokine was released by NHDF cells.
Larry G. Arlian, PhD (Committee Chair)
Barbara Hull, PhD (Committee Member)
Courtney Sulentic, PhD (Committee Member)
David Goldstein, PhD (Other)
Andrew Hsu, PhD (Other)
115 p.

Recommended Citations

Citations

  • Rockwood, J. (2012). House Dust Mite Induced Gene Expression and Cytokine Secretion by Human Dermal Fibroblasts [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1347976529

    APA Style (7th edition)

  • Rockwood, Jananie. House Dust Mite Induced Gene Expression and Cytokine Secretion by Human Dermal Fibroblasts. 2012. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1347976529.

    MLA Style (8th edition)

  • Rockwood, Jananie. "House Dust Mite Induced Gene Expression and Cytokine Secretion by Human Dermal Fibroblasts." Master's thesis, Wright State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1347976529

    Chicago Manual of Style (17th edition)