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new_thesis_nombered_draft.pdf (559.54 KB)
ETD Abstract Container
Abstract Header
NOVEL APPROACHES FOR THE ERADICATION OF HIV LATENTLY INFECTED CELLS
Author Info
Al Ali, Sally
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=wright1377374244
Abstract Details
Year and Degree
2013, Master of Science (MS), Wright State University, Microbiology and Immunology.
Abstract
The development of a suitable experimental cell model to study HIV latency in primary cells could have a massive effect on the current approaches to eradicate virus in latently infected cells. The main proposal of this paper is to develop an in vitro HIV cell model that represents HIV latency in vivo, then to create a more effective viral vector in order to target HIV reservoirs. For this goal, a directed evolution method is suggested to be used in order to mutate the AAV cap gene to generate a recombinant AAV vector that is capable of infecting primary resting CD4+ T cells previously infected with HIV-1 and in a latent stage.
Committee
Dawn P. Wooley, Ph.D. (Committee Chair)
Katherine Excoffon, Ph.D. (Committee Member)
Barbara E. Hull, Ph.D. (Committee Member)
Pages
33 p.
Subject Headings
Biomedical Research
;
Immunology
;
Microbiology
;
Virology
Keywords
microbiology
;
immunology
;
biomedical research
;
virology
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Citations
Al Ali, S. (2013).
NOVEL APPROACHES FOR THE ERADICATION OF HIV LATENTLY INFECTED CELLS
[Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1377374244
APA Style (7th edition)
Al Ali, Sally.
NOVEL APPROACHES FOR THE ERADICATION OF HIV LATENTLY INFECTED CELLS.
2013. Wright State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=wright1377374244.
MLA Style (8th edition)
Al Ali, Sally. "NOVEL APPROACHES FOR THE ERADICATION OF HIV LATENTLY INFECTED CELLS." Master's thesis, Wright State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1377374244
Chicago Manual of Style (17th edition)
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Document number:
wright1377374244
Download Count:
406
Copyright Info
© 2013, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.