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AMP-Activated Protein Kinase Knockdown in Labyrinthine Trophoblast Cells Results in Altered Morphology and Function

Carey, Erica Ashton Kayleigh
http://rave.ohiolink.edu/etdc/view?acc_num=wright1377417590

Abstract Details

2013, Master of Science (MS), Wright State University, Microbiology and Immunology.
The placenta is a transient organ that develops upon initiation of pregnancy and is essential for fetal development and survival. The rodent placenta consists of three layers with predominantly analogous cell types in the human placenta. The labyrinth layer, which lies closest to the fetus, facilitates nutrient and waste exchange between mother and baby. Abnormalities of the placenta may occur as a result of cellular stress and have been associated with the pregnancy-associated disorders, intrauterine growth restriction and placental insufficiency. AMP-activated protein kinase (AMPK) is a master sensor of cellular stress and changes in AMPK expression or activation could be detrimental to the cells ability to function. To study the role of AMPK in the placenta, we used RNA interference to knock down levels of both AMPK isoforms, AMPKα1 and AMPKα2 in SM10 labyrinthine progenitor cells, and analyzed the effects on important cellular functions, including growth, differentiation, and nutrient transport.
Thomas Brown, Ph.D (Advisor)
Christopher Wyatt, Ph.D. (Committee Member)
Robert Putnam, Ph.D. (Committee Member)
64 p.
Biology; Biomedical Research
nutrient transport; glucose; placenta; pregnancy; AMPK

Recommended Citations

Citations

  • Carey, E. A. K. (2013). AMP-Activated Protein Kinase Knockdown in Labyrinthine Trophoblast Cells Results in Altered Morphology and Function [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1377417590

    APA Style (7th edition)

  • Carey, Erica. AMP-Activated Protein Kinase Knockdown in Labyrinthine Trophoblast Cells Results in Altered Morphology and Function. 2013. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1377417590.

    MLA Style (8th edition)

  • Carey, Erica. "AMP-Activated Protein Kinase Knockdown in Labyrinthine Trophoblast Cells Results in Altered Morphology and Function." Master's thesis, Wright State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1377417590

    Chicago Manual of Style (17th edition)

wright1377417590
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© 2013, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.