Skip to Main Content
 

Global Search Box

 
 
 
 

ETD Abstract Container

Abstract Header

Type I Interferon Activation of Natural Killer (NK) Cells by Cytomegalovirus (CMV) and Their Interaction with Dendritic (DC) and NKT Cells.

Oulad Abdelati, Howaida A.

Abstract Details

2013, Master of Science (MS), Wright State University, Microbiology and Immunology.
In our current study the roles of natural killer (NK) cells in regulation of the acute phase of murine cytomegalovirus (MCMV) infection were demonstrated. NK cells utilize perforin and gamma interferon to kill MCMV infected cells. Activation of NK cells is controlled by the balance between inhibitory and activation receptors and modulated by cytokines produced from the infected cells. Type I interferons are produced mainly by plasmacytoid dendritic cells (PDCs). Type I interferons have a substantial role in enhancing NK cells cytotoxic activity and NK cells proliferation and maintain cell survival through STAT mediated signaling pathway. IL-12 produced by dendritic cells activates NK cells and natural killer T (NKT) cells. Natural killer T cells activate NK cells through IFN-Y production at early time during MCMV infection. These immune cells and their produced cytokines are critical to regulate MCMV infection and any disturbance of this activation will lead to impaired host innate immunity.
Nancy Bigley, PhD (Advisor)
Barbara Hull, PhD (Committee Member)
Cheryl Conley, PhD (Committee Member)
52 p.

Recommended Citations

Citations

  • Oulad Abdelati, H. A. (2013). Type I Interferon Activation of Natural Killer (NK) Cells by Cytomegalovirus (CMV) and Their Interaction with Dendritic (DC) and NKT Cells. [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1389625313

    APA Style (7th edition)

  • Oulad Abdelati, Howaida. Type I Interferon Activation of Natural Killer (NK) Cells by Cytomegalovirus (CMV) and Their Interaction with Dendritic (DC) and NKT Cells. 2013. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1389625313.

    MLA Style (8th edition)

  • Oulad Abdelati, Howaida. "Type I Interferon Activation of Natural Killer (NK) Cells by Cytomegalovirus (CMV) and Their Interaction with Dendritic (DC) and NKT Cells." Master's thesis, Wright State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1389625313

    Chicago Manual of Style (17th edition)