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Utility of a Volume-Regulated Drive System for Direct Mechanical Ventricular Actuation

Schmitt, Benjamin A.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1389634127

Abstract Details

2013, Master of Science in Engineering (MSEgr), Wright State University, Biomedical Engineering.
Direct Mechanical Ventricular Actuation (DMVA) is a non-blood contacting cardiac assist device that augments ventricular function. The purpose of this study was to determine if a volume-regulated “hand pump” drive system and a pressure-regulated “switch tank” drive system provide equivalent levels of cardiac support. Canine (n=2) and swine (n=4) were instrumented for hemodynamic monitoring and intravascular echocardiography. DMVA support was assessed during both severe heart failure and fibrillation. Pump function was evaluated using hemodynamic measures to calculate stroke work. Myocardial function was assessed using echocardiographic speckle tracking to quantify strain rate. Results were compared between groups using paired t-tests. There were no significant differences in either pump function or myocardial strain rates between the hand pump versus switch tank during support of either the failing or fibrillating heart. These results suggest functional equivalency between the two drive system mechanisms that supports development of an automated volume-regulated system, with its corresponding benefits in reduced size, portability, and potential user-friendly control.
David Reynolds, Ph.D. (Committee Co-Chair)
Mark Anstadt, M.D. (Committee Co-Chair)
Chandler Phillips, M.D. (Committee Member)
46 p.
Biomedical Engineering; Medical Imaging
Direct Mechanical Ventricular Actuation; Mechanical Circulatory Support; Echocardiography; Speckle Tracking; Strain Rate; Myocardial Stretch

Recommended Citations

Citations

  • Schmitt, B. A. (2013). Utility of a Volume-Regulated Drive System for Direct Mechanical Ventricular Actuation [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1389634127

    APA Style (7th edition)

  • Schmitt, Benjamin. Utility of a Volume-Regulated Drive System for Direct Mechanical Ventricular Actuation. 2013. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1389634127.

    MLA Style (8th edition)

  • Schmitt, Benjamin. "Utility of a Volume-Regulated Drive System for Direct Mechanical Ventricular Actuation." Master's thesis, Wright State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1389634127

    Chicago Manual of Style (17th edition)

wright1389634127
571
© 2013, some rights reserved.Creative Commons License Utility of a Volume-Regulated Drive System for Direct Mechanical Ventricular Actuation by Benjamin A. Schmitt is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.