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Effects of Transcranial Direct Current Stimulation on Expression of Immediate Early Genes (IEG’s)

Wagner, Jessica

Abstract Details

2014, Master of Science (MS), Wright State University, Physiology and Neuroscience.
Transcranial direct current stimulation (tDCS) has been utilized in human studies to modulate a multitude of psychological, cognitive, and psychiatric disorders. There have been positive behavioral results in human subjects but our knowledge of biological processes occurring during stimulation to elicit behavioral outcomes is limited. Our study utilizes a rodent tDCS (R-tDCS) model in which Sprague Dawley rats receive tDCS in order to examine whether tDCS affects neuronal activation. We examined two immediate early genes (IEG’s), cFos and zif268, in order to discern if tDCS affects neuronal activation. Our findings indicate that tDCS does affect neuronal activation by means of IEG induction and that there is dose dependence between current intensity used and mRNA levels of IEG’s. These findings are important because they show biologically tDCS affecting neuronal activation. This study aided the scientific community in better understanding what is occurring biologically during tDCS.
Ryan Jankord, Ph.D. (Advisor)
Larry Ream, Ph.D. (Committee Member)
David Ladle, Ph.D. (Committee Member)
54 p.

Recommended Citations

Citations

  • Wagner, J. (2014). Effects of Transcranial Direct Current Stimulation on Expression of Immediate Early Genes (IEG’s) [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1407255006

    APA Style (7th edition)

  • Wagner, Jessica. Effects of Transcranial Direct Current Stimulation on Expression of Immediate Early Genes (IEG’s). 2014. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1407255006.

    MLA Style (8th edition)

  • Wagner, Jessica. "Effects of Transcranial Direct Current Stimulation on Expression of Immediate Early Genes (IEG’s)." Master's thesis, Wright State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1407255006

    Chicago Manual of Style (17th edition)