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A whole thesis, Salmin Ali.pdf (1.43 MB)
ETD Abstract Container
Abstract Header
GLUT 4 and Insulin Resistance
Author Info
Ali, Salmin
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=wright1409746939
Abstract Details
Year and Degree
2014, Master of Science (MS), Wright State University, Microbiology and Immunology.
Abstract
Five types of glucose transporters stimulate the transport of glucose from the bloodstream into cells such as muscle cells and adipocytes in response to insulin signaling or exercise. Skeletal muscle and adipose tissue are the main sites for glucose uptake and dispose in insulin action dependent pathway. In non-insulin stimulated condition, the GLUT4 storage vesicles stay away from the plasma membrane, so there is no GLUT4 translocation or GLUT4 mediated glucose uptake. However, in insulin stimulated state, insulin initiates insulin signaling cascade which results in rapid GLUT4 translocation and increased glucose uptake at the cell surface. Failure of the translocation of GLUT4 storage compartments into the plasma membrane in response to insulin stimulation or exercise may reduce the GLUT4 mediated glucose uptake and thus insulin resistance and type 2 DM development.
Committee
Barbara Hull, Ph.D. (Advisor)
Nancy Bigley, Ph.D. (Committee Member)
John Paietta, Ph.D. (Committee Member)
Pages
40 p.
Subject Headings
Immunology
;
Microbiology
Keywords
immunology
;
microbiology
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Citations
Ali, S. (2014).
GLUT 4 and Insulin Resistance
[Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1409746939
APA Style (7th edition)
Ali, Salmin.
GLUT 4 and Insulin Resistance.
2014. Wright State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=wright1409746939.
MLA Style (8th edition)
Ali, Salmin. "GLUT 4 and Insulin Resistance." Master's thesis, Wright State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1409746939
Chicago Manual of Style (17th edition)
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Document number:
wright1409746939
Download Count:
3,147
Copyright Info
© 2014, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.