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Angiotensin-II receptor blocker and its effects on depressive-like behavior during maternal separation

Xanthos, Evan D.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1437154659

Abstract Details

2015, Master of Science (MS), Wright State University, Anatomy.
Maternal separation has been shown to promote the onset of adult depression. This early life stressor produces a biphasic response marked by an active “protest” phase followed by a passive “despair” phase in humans and other species. In infant guinea pigs, active phase behaviors include increased locomotion and distress vocalizations, whereas the passive phase is marked by depressive-like behaviors including a crouch stance, eye closure and piloerection. Separation elicits physiological responses including increased core body temperature and proinflammatory cytokine expression suggesting fever. Angiotensin-II receptor blockers (ARB’s) inhibit inflammation both peripherally and centrally following peripheral administration. The goal of the present study is to determine the effects the ARB blocker Losartan (Cozaar) on passive behavior and sensitization in the guinea pig. Subjects were separated into four groups: Losartan (LSEP), Vehicle (VSEP), Separated (SEP) and Undisturbed (UND). Peripheral administration was provided to LSEP and VSEP groups before the first test. Although the results of this study provided evidence of sensitization in guinea pig pups, Losartan did not decrease depressive like behavior or sensitization upon repeated maternal separations
Michael Hennessy, Ph.D. (Advisor)
Patricia Schiml, Ph.D. (Committee Member)
Larry Ream, Ph.D. (Committee Member)
43 p.
Behavioral Psychology
behavioral psychology

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Citations

  • Xanthos, E. D. (2015). Angiotensin-II receptor blocker and its effects on depressive-like behavior during maternal separation [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1437154659

    APA Style (7th edition)

  • Xanthos, Evan. Angiotensin-II receptor blocker and its effects on depressive-like behavior during maternal separation . 2015. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1437154659.

    MLA Style (8th edition)

  • Xanthos, Evan. "Angiotensin-II receptor blocker and its effects on depressive-like behavior during maternal separation ." Master's thesis, Wright State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1437154659

    Chicago Manual of Style (17th edition)

wright1437154659
435
© 2015, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.