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Rose Cooper Final thesis.pdf (3 MB)

ETD Abstract Container

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Behavior of Gold Nanoparticles in Physiological Environment and the Role of Agglomeration and Fractal Dimension.

Cooper, Rose
http://rave.ohiolink.edu/etdc/view?acc_num=wright1440168780

Abstract Details

2015, Master of Science (MS), Wright State University, Pharmacology and Toxicology.
The Present study was designed to examine the role of agglomeration, density and the resulting fractal dimension of nanomaterials in cell culture media. Studies were completed on the kinetics and the process of agglomeration, as well as how to calculate fractal dimensions. The correlation of such complex agglomeration patterns of nanomaterials in culture media, their translocation into cells, and toxic effects were observed. Our results showed that smaller primary particles agglomerated at an accelerated rate when compared to the larger primary particles. They also demonstrated increased cellular uptake, but exhibited lower fractal dimensions. The larger primary particle agglomerates displayed obvious morphology alterations. This could be a result of greater density and sedimentation, which would disrupt cellular structure. These results reveal the biological effects of agglomerates, and how various fractal dimensions may alter cellular interactions with nanoparticles.
Saber Hussain, Ph.D (Advisor)
David Cool, Ph.D. (Committee Member)
Courtney Sulentic, Ph.D. (Committee Member)
101 p.
Nanoscience; Pharmacology; Toxicology
pharmacology; toxicology; nanoscience

Recommended Citations

Citations

  • Cooper, R. (2015). Behavior of Gold Nanoparticles in Physiological Environment and the Role of Agglomeration and Fractal Dimension. [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1440168780

    APA Style (7th edition)

  • Cooper, Rose. Behavior of Gold Nanoparticles in Physiological Environment and the Role of Agglomeration and Fractal Dimension. 2015. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1440168780.

    MLA Style (8th edition)

  • Cooper, Rose. "Behavior of Gold Nanoparticles in Physiological Environment and the Role of Agglomeration and Fractal Dimension." Master's thesis, Wright State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1440168780

    Chicago Manual of Style (17th edition)

wright1440168780
2,348
© 2015, some rights reserved.Creative Commons License Behavior of Gold Nanoparticles in Physiological Environment and the Role of Agglomeration and Fractal Dimension. by Rose Cooper is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.