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Neal Verma final Thesis.pdf (1.01 MB)

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The Timing of Fluoxetine, Simvastatin and Ascorbic Acid Administration in a Post-Ischemic Stroke Environment Affects Infarct Volume and Hemorrhagic Transformation Frequency

Verma, Neal R.
http://orcid.org/0000-0002-2971-9540
http://rave.ohiolink.edu/etdc/view?acc_num=wright1464012779

Abstract Details

2016, Master of Science (MS), Wright State University, Anatomy.
Previous animal experiments have indicated that administration of fluoxetine and simvastatin at 20-26 hours post-stroke decreases the volume of ischemic infarcts. This experiment expanded on previous experiments by adding ascorbic acid to the post-stroke regimen, initiating simvastatin pre-stroke, and adding a third initiation time frame (48-54 hours). Male retired breeder Sprague-Dawley rats were on simvastatin for 7 days prior to stroke induction. Combined medications of 5 milligrams/kilogram of fluoxetine, 1 milligram/kilogram of simvastatin and 20 milligrams/kilogram of ascorbic acid were orally administered at 6-12 hours, 20-26 hours, or 48-54 hours, respectively, following stroke induction. Adult rats that were treated 20-26 hours post-stroke showed a decrease in infarct volume (15.67 ± 5.622 millimeters cubed, P=0.0098) compared to the control. The combination of simvastatin, fluoxetine and ascorbic acid decreased the relative risk (RR=0.3704 (95% confidence interval 0.0987 to 1.3905, p-value = 0.1411) of bleeding after ischemic stroke if initiated 20-26 hours after stroke induction in rats.
Adrian Corbett, Ph.D. (Advisor)
Debra Mayes, Ph.D. (Committee Member)
Mary White, Ph.D. (Committee Member)
101 p.
Cellular Biology; Histology; Neurobiology; Neurology; Neurosciences; Pharmacology; Physiology
infarct volume; ischemic stroke; rats; hemorrhagic transformation; fluoxetine; simvastatin; ascorbic acid;

Recommended Citations

Citations

  • Verma, N. R. (2016). The Timing of Fluoxetine, Simvastatin and Ascorbic Acid Administration in a Post-Ischemic Stroke Environment Affects Infarct Volume and Hemorrhagic Transformation Frequency [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1464012779

    APA Style (7th edition)

  • Verma, Neal. The Timing of Fluoxetine, Simvastatin and Ascorbic Acid Administration in a Post-Ischemic Stroke Environment Affects Infarct Volume and Hemorrhagic Transformation Frequency. 2016. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1464012779.

    MLA Style (8th edition)

  • Verma, Neal. "The Timing of Fluoxetine, Simvastatin and Ascorbic Acid Administration in a Post-Ischemic Stroke Environment Affects Infarct Volume and Hemorrhagic Transformation Frequency." Master's thesis, Wright State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1464012779

    Chicago Manual of Style (17th edition)

wright1464012779
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© 2016, some rights reserved.Creative Commons License The Timing of Fluoxetine, Simvastatin and Ascorbic Acid Administration in a Post-Ischemic Stroke Environment Affects Infarct Volume and Hemorrhagic Transformation Frequency by Neal R. Verma is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.