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FINAL_Flannery Thesis Jan 16.pdf (3.01 MB)

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Enhanced Neurogenesis In Subventricular Zone Of Rats That Voluntarily Ingest Fluoxetine And Simavastatin Combination Treatment

Flannery, Tiffany L.
http://orcid.org/0000-0002-1698-5612
http://rave.ohiolink.edu/etdc/view?acc_num=wright1484566200182717

Abstract Details

2017, Master of Science (MS), Wright State University, Biological Sciences.
Stroke is one of the leading causes of deaths as the risk factors, both controllable and uncontrollable, are many. We first concentrated on a stress-free way to deliver the drugs. Our preference was to have the animals ingest the drugs, which led us to a reliable method for orally administering medication to the animal models. Using three different drug combinations, we tested the effects on neurogenesis without stroke. We found the drug combination of Fluoxetine/Statin/Ascorbic acid increases neurogenesis 19 fold when compared with control. Lastly, we looked at the gene changes in the cortex of the animal models that had been administered our drug treatment. We noted that the fluoxetine treatment group was involved in up-regulated genes showing genetic themes related to molecular functions for channel activity and that the fluoxetine/statin combination treatment group was associated with clotting activity as well as an immune response.
Lynn Hartzler, Ph.D. (Advisor)
Adrian Corbett, Ph.D. (Committee Member)
Barbara Hull, Ph.D. (Committee Member)
115 p.
Anatomy and Physiology; Biology; Neurobiology; Pharmacology
neurogenesis; rat; subventricular zone; fluoxetine; simvastatin; voluntary oral drug delivery; sham surgery

Recommended Citations

Citations

  • Flannery, T. L. (2017). Enhanced Neurogenesis In Subventricular Zone Of Rats That Voluntarily Ingest Fluoxetine And Simavastatin Combination Treatment [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1484566200182717

    APA Style (7th edition)

  • Flannery, Tiffany. Enhanced Neurogenesis In Subventricular Zone Of Rats That Voluntarily Ingest Fluoxetine And Simavastatin Combination Treatment . 2017. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1484566200182717.

    MLA Style (8th edition)

  • Flannery, Tiffany. "Enhanced Neurogenesis In Subventricular Zone Of Rats That Voluntarily Ingest Fluoxetine And Simavastatin Combination Treatment ." Master's thesis, Wright State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1484566200182717

    Chicago Manual of Style (17th edition)

wright1484566200182717
535
© 2017, some rights reserved.Creative Commons License Enhanced Neurogenesis In Subventricular Zone Of Rats That Voluntarily Ingest Fluoxetine And Simavastatin Combination Treatment by Tiffany L. Flannery is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.