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Early Assessment of Burn Severity in Human Tissue with Multi-Wavelength Spatial Frequency Domain Imaging

Poon, Chien Sing
http://orcid.org/0000-0002-3064-8209
http://rave.ohiolink.edu/etdc/view?acc_num=wright1484582176416423

Abstract Details

2016, Master of Science in Biomedical Engineering (MSBME), Wright State University, Biomedical Engineering.
Burn injuries such as thermal burns, which are caused by contact with flames, hot liquids, hot surfaces, and other sources of high heat as well as chemical burns and electrical burns, affects at least 500,000 people in the United States, to which 45,000 of them require medical treatment and 3,500 of them result in death. It has also been reported that in the United States alone, fire results in a death approximately every three hours and an injury every 33 minutes. Early knowledge about burn severity can lead to improved outcome for patients. In this study, the changes in optical properties in human skin following thermal burn injuries were investigated. Human skin removed during body contouring procedures was burned for either 10 or 60 seconds using a metal block placed in boiling water. Multi-wavelength spatial frequency domain imaging (SFDI) measurements were performed on each sample and the optical properties (absorption and scattering parameters) were obtained at each wavelength. Multi-wavelength fitting was used to quantify scattering parameters, and these parameters were compared to histologic assessments of burn severity. Our results indicate substantial changes in optical parameters and changes, which correlate well with respect to burn severity. This study shows the characterization of thermal burn injury on human skin ex vivo by using the optical method of SFDI with high sensitivity and specificity. Due to more challenging conditions of layered skin structures with differing thickness in humans, ongoing work tackles combining high-resolution ultrasound imaging with SFDI for more accurate quantification of optical properties during in vivo clinical studies.
Ulas Sunar, Ph.D. (Committee Chair)
Ping He, Ph.D. (Committee Member)
Jeffrey Travers, M.D. Ph.D. (Committee Member)
91 p.
Biomedical Engineering; Biomedical Research; Biophysics; Cellular Biology; Engineering; Medical Imaging; Optics; Physics
Optical Imaging; Medical Imaging; burn wound assessment; diagnosis; fluorescence; multispectral imaging; optical properties; quantitative assessment; skin burn; spatial frequency domain imaging; system; tissue scattering; wounds

Recommended Citations

Citations

  • Poon, C. S. (2016). Early Assessment of Burn Severity in Human Tissue with Multi-Wavelength Spatial Frequency Domain Imaging [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1484582176416423

    APA Style (7th edition)

  • Poon, Chien Sing. Early Assessment of Burn Severity in Human Tissue with Multi-Wavelength Spatial Frequency Domain Imaging . 2016. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1484582176416423.

    MLA Style (8th edition)

  • Poon, Chien Sing. "Early Assessment of Burn Severity in Human Tissue with Multi-Wavelength Spatial Frequency Domain Imaging ." Master's thesis, Wright State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1484582176416423

    Chicago Manual of Style (17th edition)

wright1484582176416423
846
© 2016, some rights reserved.Creative Commons License Early Assessment of Burn Severity in Human Tissue with Multi-Wavelength Spatial Frequency Domain Imaging by Chien Sing Poon is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.