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Cross Sensitization of Depressive-Like Behavior through Two Depression Related Paradigms: Maternal Separation and Its Effect on the Forced Swim Test In the Guinea Pig

Schreibeis, Amanda Danielle
http://rave.ohiolink.edu/etdc/view?acc_num=wright1484638271891606

Abstract Details

2016, Master of Science (MS), Wright State University, Physiology and Neuroscience.
Separation and Its Effect on the Forced Swim Test In the Guinea Pig Early-life stress such as parental neglect, absence, or abandonment, has been hypothesized to increase the susceptibility for developing depression later in life via sensitization of stress-responsive physiological systems (e.g., pro-inflammatory cytokines, hypothalamic-pituitary-adrenal axis). Guinea pigs offer a potential model, but study has been limited to behavioral observations obtained during maternal separation tests. This thesis examined the generalization of this response by asking whether it would cross-sensitize to behavior in another depressive-related paradigm, the forced swim test. In three experiments, pups underwent three forced swim trials, in shallower or deeper water, 24 h or 9 days after 3-h separation period(s). Immobility duration and latency served as the primary dependent measures. I observed cross sensitization of depressive-like behavior (longer duration of immobility) when pups were tested in the deeper water forced swim test 24 h following maternal separation. Results further confirm use of the guinea pig separation model and suggest sensitization of an underlying depressive-like state rather than particular depressive-like behaviors.
Michael Hennessy, Ph.D (Advisor)
Patricia Schiml, Ph.D (Committee Member)
Michal Kraszpulski, Ph.D (Committee Member)
40 p.
Developmental Psychology; Neurosciences; Psychobiology
Cross-sensitization; Depression; Early Life Stress; Guinea Pig

Recommended Citations

Citations

  • Schreibeis, A. D. (2016). Cross Sensitization of Depressive-Like Behavior through Two Depression Related Paradigms: Maternal Separation and Its Effect on the Forced Swim Test In the Guinea Pig [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1484638271891606

    APA Style (7th edition)

  • Schreibeis, Amanda. Cross Sensitization of Depressive-Like Behavior through Two Depression Related Paradigms: Maternal Separation and Its Effect on the Forced Swim Test In the Guinea Pig. 2016. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1484638271891606.

    MLA Style (8th edition)

  • Schreibeis, Amanda. "Cross Sensitization of Depressive-Like Behavior through Two Depression Related Paradigms: Maternal Separation and Its Effect on the Forced Swim Test In the Guinea Pig." Master's thesis, Wright State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1484638271891606

    Chicago Manual of Style (17th edition)

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© 2016, some rights reserved.Creative Commons License Cross Sensitization of Depressive-Like Behavior through Two Depression Related Paradigms: Maternal Separation and Its Effect on the Forced Swim Test In the Guinea Pig by Amanda Danielle Schreibeis is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.