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Optical Redox Imaging of Metabolic Activity

Zaidi, Syed Anwar Hyder
http://rave.ohiolink.edu/etdc/view?acc_num=wright1484672916027993

Abstract Details

2016, Master of Science in Biomedical Engineering (MSBME), Wright State University, Biomedical Engineering.
Fluorescence imaging can be used to determine tissue metabolism, which is an indication of the cellular functionality. Metabolic contrast is useful for the early detection of several medical conditions such as cancer, diabetes, lung diseases etc. This study aims to use fluorescence imaging to quantify NADH and FAD, which are cellular metabolic indicators. A parameter known as Redox ratio, can be used to study metabolic state of several tissue types and disease states. To quantify the Redox ratio, three fluorescence imaging systems were optimized to measure the fluorescence signal from NADH and FAD. The first system was a camera based model suitable for laboratory and clinical settings. The second and third were compact versions of the same instrument. The systems were characterized and brain cancer cells were measured using the camera-based system and the compact model, which resulted in a similar Redox ratio.
Ulas Sunar, Ph.D. (Advisor)
Jaime Ramirez-Vick, Ph.D. (Committee Member)
Debra Mayes, Ph.D. (Committee Member)
140 p.
Biomedical Engineering; Biomedical Research; Biophysics; Electrical Engineering; Medical Imaging; Optics
Fluorescence imaging; cancer diagnosis; compact devices; wireless devices; optical imaging

Recommended Citations

Citations

  • Zaidi, S. A. H. (2016). Optical Redox Imaging of Metabolic Activity [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1484672916027993

    APA Style (7th edition)

  • Zaidi, Syed Anwar Hyder. Optical Redox Imaging of Metabolic Activity. 2016. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1484672916027993.

    MLA Style (8th edition)

  • Zaidi, Syed Anwar Hyder. "Optical Redox Imaging of Metabolic Activity." Master's thesis, Wright State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1484672916027993

    Chicago Manual of Style (17th edition)

wright1484672916027993
731
© 2016, some rights reserved.Creative Commons License Optical Redox Imaging of Metabolic Activity by Syed Anwar Hyder Zaidi is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Wright State University and OhioLINK.