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Exploring Gender Differences Throughout Normal Rat Aging - A Role for Estrogen Signaling in the Brain

Evola, Christopher Mark
http://rave.ohiolink.edu/etdc/view?acc_num=wright1525089104502219

Abstract Details

2018, Master of Science (MS), Wright State University, Anatomy.
Females are more protected than males from neurodegenerative diseases until they go through menopause when this protection drops dramatically. It has been hypothesized that this neuroprotection is hormone-dependent. The current study characterized cell signaling molecules downstream of estrogen receptor beta that are known to play a role in memory, PKC, ERK, and connexin-43, in regions of the brain associated with memory decline in an attempt to elucidate significant changes that occur post-estrus. Total whole cell lysates were compared to isolated mitochondrial protein because mitochondrial function is known to be altered during aging. As hypothesized, protein concentrations differed depending on age, gender, and brain region. Additionally, many of these changes occurred within mitochondria but not within whole cell lysates indicating that these are epigenetic alterations. These findings accentuate the complexity of aging and provide insight into the gender-specific cellular processes that occur throughout this process.
Debra Mayes, Ph.D. (Advisor)
Adrian Corbett, Ph.D. (Committee Member)
Nancy Bigley, Ph.D. (Committee Member)
127 p.
Aging; Anatomy and Physiology; Gender; Neurosciences
Aging; Cortex; Hippocampus; Amygdala; Corpus Callosum; Cerebellum; PKC; ERK; Cx43; ER-beta; Ponceau; ATP synthase; Beta-actin

Recommended Citations

Citations

  • Evola, C. M. (2018). Exploring Gender Differences Throughout Normal Rat Aging - A Role for Estrogen Signaling in the Brain [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1525089104502219

    APA Style (7th edition)

  • Evola, Christopher. Exploring Gender Differences Throughout Normal Rat Aging - A Role for Estrogen Signaling in the Brain. 2018. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1525089104502219.

    MLA Style (8th edition)

  • Evola, Christopher. "Exploring Gender Differences Throughout Normal Rat Aging - A Role for Estrogen Signaling in the Brain." Master's thesis, Wright State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1525089104502219

    Chicago Manual of Style (17th edition)

wright1525089104502219
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© 2018, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.