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Design of a Novel Tissue Culture System to Subject Aortic Tissue to Multidirectional Bicuspid Aortic Valve Wall Shear Stress

Liu, Janet
http://rave.ohiolink.edu/etdc/view?acc_num=wright1527077368757049

Abstract Details

2018, Master of Science in Mechanical Engineering (MSME), Wright State University, Mechanical Engineering.
Blood vessels experience complex hemodynamics marked by three-dimensionality and pulsatility. Arterial endothelial cells interact with the characteristics of the fluid wall shear stress (WSS) to maintain homeostasis or promote disease states. In particular, the bicuspid aortic valve (BAV), a congenital heart valve anatomy consisting of two leaflets instead of three, is associated with aortic complications presumably promoted by hemodynamic abnormalities. While devices have been used to test this hypothesis, their capabilities are limited to the generation of time-varying WSS magnitude in one direction. However, the increased flow helicity generated by BAVs in the aorta is expected to result in increased WSS multidirectionality. Therefore, the objectives of this thesis were to characterize the magnitude and directionality of the regional WSS in a BAV aorta, and to design a bioreactor capable of replicating these characteristics in vitro. This device will provide new insights into the mechanobiology of BAV aortopathy and other flow-mediated cardiovascular diseases.
Philippe Sucosky, Ph.D. (Advisor)
Zifeng Yang, Ph.D. (Committee Member)
Jaime Ramirez-Vick, Ph.D. (Committee Member)
126 p.
Biomedical Engineering; Mechanical Engineering
Bicuspid aortic valve; Aortic dilation; Wall shear stress; WSS; Fluid shear stress bioreactor; Bioreactor; Aortopathy; Aorta; Helicity; Directionality; Multidirectional; Hemodynamics; Computational fluid dynamics; CFD

Recommended Citations

Citations

  • Liu, J. (2018). Design of a Novel Tissue Culture System to Subject Aortic Tissue to Multidirectional Bicuspid Aortic Valve Wall Shear Stress [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1527077368757049

    APA Style (7th edition)

  • Liu, Janet. Design of a Novel Tissue Culture System to Subject Aortic Tissue to Multidirectional Bicuspid Aortic Valve Wall Shear Stress. 2018. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1527077368757049.

    MLA Style (8th edition)

  • Liu, Janet. "Design of a Novel Tissue Culture System to Subject Aortic Tissue to Multidirectional Bicuspid Aortic Valve Wall Shear Stress." Master's thesis, Wright State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1527077368757049

    Chicago Manual of Style (17th edition)

wright1527077368757049
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© 2018, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.