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Kajal Kamra Masters Thesis 2019.pdf (1.34 MB)

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Effect of Administration of Somatostatin Analogue on Blood Pressure in Chronic Intermittent Hypoxic Rats

Kamra, Kajal
http://rave.ohiolink.edu/etdc/view?acc_num=wright155791784103344

Abstract Details

2019, Master of Science (MS), Wright State University, Physiology and Neuroscience.
The cardiorespiratory system in our bodies does not adapt to Chronic Intermittent Hypoxia (CIH) and consequently syndromes such as sleep apnea lead to pathophysiological conditions like Hypertension. It has been demonstrated that the peripheral chemoreceptors underpin the development of these conditions and at present, there are no selective drug therapies for this form of hypertension. However, evidence suggests that peripheral chemoreflex sensitivity to CO2 & hypoxia is reduced by Somatostatin (SST) in humans. Our preliminary in-vitro studies have demonstrated that SST will blunt the response of the carotid body to hypoxia and decrease the baseline activity of the carotid body. We therefore hypothesize that SST analogues given in-vivo via osmotic minipumps will attenuate the increase in BP, thereby preventing systemic hypertension from developing during CIH. Adult male Sprague-Dawley rats were implanted with Osmotic minipumps containing sterile water or SST analogue (Octreotide Acetate) and then were exposed to CIH for ≤35 days to induce hypertension. BPs were measured before, during and after IH conditioning. Each minipump administers the drug for only 28 days. It was predicted that the animals exposed to the SST analogue will be protected from CIH-induced hypertension. Data showed a sudden drop in BP post-surgery in all animals tested. This hypotension may have prevented the ability of chronic intermittent hypoxia to induce hypertension in both experimental and control animals.
Christopher Wyatt, Ph.D. (Advisor)
Kathrin Engisch, Ph.D. (Committee Member)
Clintoria Williams, Ph.D. (Committee Member)
113 p.
Physiology
Carotid Body; somatostatin; hypertension

Recommended Citations

Citations

  • Kamra, K. (2019). Effect of Administration of Somatostatin Analogue on Blood Pressure in Chronic Intermittent Hypoxic Rats [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright155791784103344

    APA Style (7th edition)

  • Kamra, Kajal. Effect of Administration of Somatostatin Analogue on Blood Pressure in Chronic Intermittent Hypoxic Rats. 2019. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright155791784103344.

    MLA Style (8th edition)

  • Kamra, Kajal. "Effect of Administration of Somatostatin Analogue on Blood Pressure in Chronic Intermittent Hypoxic Rats." Master's thesis, Wright State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright155791784103344

    Chicago Manual of Style (17th edition)

wright155791784103344
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© 2019, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.