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Assessing the role of Polyphenols as a vascular protectant against Drug Induced Vascular Injury.

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2019, Master of Science in Biomedical Engineering (MSBME), Wright State University, Biomedical Engineering.
Vascular injury is identified during pre-clinical toxicity testing within certain pharmacological classes of drug candidates and induces degenerative and hyperplastic changes in endothelial (ECs) and vascular smooth muscle (VSMCs) cells. This drug-induced vascular injury has been show as a side-effect caused by various classes of drugs, including, antibacterial (e.g., azithromycin), anti-malarial (e.g., quinoline), anti-viral (e.g., anti-hepatitis C virus interferons) and nonsteroidal anti-inflammatory drugs (e.g., ibuprofen), and affects normal cardiovascular function and can further lead to various cardiovascular conditions like arrhythmia, cardiac arrest, high blood pressure, and even heart attack. The search for agents capable of reducing vascular injury side-effects by drugs is a very active and important pharmacological field. Dietary polyphenols have been shown to protect the vasculature against drug-induced vascular injury by directly affecting both, VSMCs and ECs. We propose polyphenols like pentagalloyl glucose (PGG), punicalagin and quercetin can be an excellent choice as a vascular protectant against the injury caused by drugs used to treat disease. Our study focusses on the a) development of an ex vivo rat aortic model under a peristaltic flow, and b) testing the vascular protective effects of different polyphenols when our model system is exposed to drugs affecting the vasculature. We will focus on three polyphenols (i.e., PGG, punicalagin, and quercetin) and two drugs (i.e., acetylcholine and phenylephrine). With acetylcholine, known to induce EC-dependent vasodilation, and phenylephrine, known to induced contraction of VSMCs. Result will show the damage caused by drugs on untreated vasculature when compared to those treated with polyphenols.
Jaime Ramirez-Vick, Ph.D. (Advisor)
Nasim Nosoudi, Ph.D. (Committee Member)
Amir Zadeh, Ph.D. (Committee Member)
29 p.

Recommended Citations

Citations

  • Oommen, A. J. (2019). Assessing the role of Polyphenols as a vascular protectant against Drug Induced Vascular Injury. [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1560292217772559

    APA Style (7th edition)

  • Oommen, Anson. Assessing the role of Polyphenols as a vascular protectant against Drug Induced Vascular Injury. 2019. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1560292217772559.

    MLA Style (8th edition)

  • Oommen, Anson. "Assessing the role of Polyphenols as a vascular protectant against Drug Induced Vascular Injury." Master's thesis, Wright State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1560292217772559

    Chicago Manual of Style (17th edition)