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Chondroitin Sulfate Hydrogels for Total Wound Care Devices

Goswami, Tushar
http://rave.ohiolink.edu/etdc/view?acc_num=wright1578587475393225

Abstract Details

2019, Master of Science in Biomedical Engineering (MSBME), Wright State University, Biomedical Engineering.
Chondroitin sulfate (CS) is a naturally occurring bio-polymer found in areas of high cartilage in mammals. In directed applications, such as hydrogels, CS can be used to impact keratinocyte growth cycles. In this work, CS based hydrogels were utilized to accelerate wound healing and, in conjunction with a graphene sensor, monitor wound fluid pH. The hydrogels were cast onto a graphene field effect transistor (GFET) to obtain the benefits of the hydrogel wound healing capabilities, while also utilizing the pH sensitivity of the graphene. Results showed that the hydrogel caused a fivefold increase in cell size over the course of 5 days compared to the control, and accelerated keratinocyte proliferation by an average of 81% when compared to a control. The GFET resistance changed as a function of pH, however, the resulting pH response was parabolic. Further investigation into pH sensitive 2D materials may be necessary in order to optimize and fabricate a functional wound monitoring device.
Caroline G.L. Cao, Ph.D. (Advisor)
John C. Gallagher, Ph.D. (Committee Member)
Tarun Goswami, D.Sc. (Committee Member)
Ulas Sunar, Ph.D. (Committee Member)
Lawrence Drummy, Ph.D. (Committee Member)
102 p.
Biomedical Engineering
wound healing; biomaterials; biopolymers; graphene; gFET; wound monitoring

Recommended Citations

Citations

  • Goswami, T. (2019). Chondroitin Sulfate Hydrogels for Total Wound Care Devices [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1578587475393225

    APA Style (7th edition)

  • Goswami, Tushar. Chondroitin Sulfate Hydrogels for Total Wound Care Devices . 2019. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1578587475393225.

    MLA Style (8th edition)

  • Goswami, Tushar. "Chondroitin Sulfate Hydrogels for Total Wound Care Devices ." Master's thesis, Wright State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1578587475393225

    Chicago Manual of Style (17th edition)

wright1578587475393225
279
© 2019, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.