Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


Matthew Murphy's Final Thesis.pdf (2.52 MB)

ETD Abstract Container

Abstract Header

Investigating the Effects of CyPPA on Small-Conductance Calcium-Activated Potassium Channels in SOD1G93A Transgenic Mouse Model

Murphy, Matthew M.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1589929963490428

Abstract Details

2020, Master of Science (MS), Wright State University, Anatomy.
Amyotrophic Lateral Sclerosis is a fatal, progressive, neurodegenerative disease. There currently is no cure for the disease and limited treatment options have modest effects. A hallmark of the disease is motoneuron degeneration. Within the membrane of motoneurons are small-conductance calcium-activated potassium channels. SK Channels function to mediate medium afterhyperpolarization period of an action potential and have substantial influence on the firing rate of motoneurons. SK channels, specifically SK2 and SK3 isoforms, have been shown through immunohistochemistry to be affected in the SOD1G93A mouse model. The goal of this study was to investigate whether neonatal administration of CyPPA, a potent SK2 and SK3 activator, had effects on the clustering of SK2 and SK3 channels in the SOD1G93A mouse model. To explore this, immunohistochemistry was performed at postnatal day 21 and day 90 and determined that CyPPA had influence on the clustering profile of both SK channel isoforms in wild-type and SOD1G93A.
Sherif Elbasiouny, Ph.D., P.E. (Advisor)
David R. Ladle, Ph.D. (Committee Member)
Keiichiro Susuki, M.D., Ph.D. (Committee Member)
99 p.
Neurosciences
ALS; SK Channel; SOD1; Amyotrophic Lateral Sclerosis; CyPPA

Recommended Citations

Citations

  • Murphy, M. M. (2020). Investigating the Effects of CyPPA on Small-Conductance Calcium-Activated Potassium Channels in SOD1G93A Transgenic Mouse Model [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1589929963490428

    APA Style (7th edition)

  • Murphy, Matthew. Investigating the Effects of CyPPA on Small-Conductance Calcium-Activated Potassium Channels in SOD1G93A Transgenic Mouse Model. 2020. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1589929963490428.

    MLA Style (8th edition)

  • Murphy, Matthew. "Investigating the Effects of CyPPA on Small-Conductance Calcium-Activated Potassium Channels in SOD1G93A Transgenic Mouse Model." Master's thesis, Wright State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1589929963490428

    Chicago Manual of Style (17th edition)

wright1589929963490428
68
© 2020, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.