Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


ysu1220366478.pdf (646.95 KB)

ETD Abstract Container

Abstract Header

Testing glycomimetic compounds for their ability to disrupt capsular polysaccharide production in type 5 Staphylococcus aureus

Pavlidakey, Katherine Irene
http://rave.ohiolink.edu/etdc/view?acc_num=ysu1220366478

Abstract Details

2008, Master of Science in Chemistry, Youngstown State University, Department of Chemistry.
The potentially fatal nature of Staphylococcus aureus is exponentially enhanced by its incredible ability to evade medical treatment. At the current time S. aureus has developed resistance mechanisms to every class of antibiotics that are supposed to inhibit or kill the bacterium. Physiologically S. aureus is able to evade host immunological defense mechanisms due to the presence of a structure known as the capsular polysaccharide. Inhibiting production of the capsular polysaccharide provides a novel approach to combating antibiotic resistant S. aureus. By targeting the synthesis of the sugars that make up the capsule, compounds can be developed that may inhibit capsule formation. These sugars are specifically targeted via glycomimetics. The mimetic compounds are tested to determine their ability to inhibit production of the capsular polysaccharide of S. aureus. The ability of the mimetic to block capsular polysaccharide production can be measured by analyzing the binding of monoclonal antibodies to the capsule.
Peter Norris, PhD (Advisor)
Diana Fagan, PhD (Advisor)
Brian Leskiw, PhD (Committee Member)
45 p.
Biology; Chemistry; Health Care; Immunology
Carbohydrate mimetics; capsular polysaccharide; testing glycomimetic compounds; Antibiotic Resistant Staphylococcus aureus

Recommended Citations

Citations

  • Pavlidakey, K. I. (2008). Testing glycomimetic compounds for their ability to disrupt capsular polysaccharide production in type 5 Staphylococcus aureus [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1220366478

    APA Style (7th edition)

  • Pavlidakey, Katherine. Testing glycomimetic compounds for their ability to disrupt capsular polysaccharide production in type 5 Staphylococcus aureus. 2008. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu1220366478.

    MLA Style (8th edition)

  • Pavlidakey, Katherine. "Testing glycomimetic compounds for their ability to disrupt capsular polysaccharide production in type 5 Staphylococcus aureus." Master's thesis, Youngstown State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1220366478

    Chicago Manual of Style (17th edition)

ysu1220366478
598
© 2008, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.