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Synthesis and Structural Analysis of Novel Bis(triazole) UDP Analogs as Potential Glycosyl Transferase Inhibitors

Knapp, Steven E.

Abstract Details

2008, Master of Science in Chemistry, Youngstown State University, Department of Chemistry.
The following details the synthesis of a novel bis(1,2,3-triazole), which is a potential glycosyltransferase inhibitor. A glycosyltransferase is an enzyme that is involved in the synthesis of polysaccharides, for example the capsule that protects Staphylococcus aureus. Bis(1,2,3-triazoles) may mimic the UDP conjugates of aminosugars (D-ManNAcA, D-FucNAc, and L-FucNAc) found in the capsular polysaccharide of S. aureus, and may prevent the formation of the capsular polysaccharide leaving the bacteria open to attack by phagocytosis or antibiotics. Bis(1,2,3-triazole) groups will be used to replace the phosphate linkages in the UDP-parent aminosugars. Bis(1,2,3-triazoles) may mimic the diphosphate linkage in binding to a transferase due to the N-3 lone pairs on the heterocycles.
Peter Norris, PhD (Advisor)
John Jackson, PhD (Committee Member)
Nina Stourman, PhD (Committee Member)
229 p.

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Citations

  • Knapp, S. E. (2008). Synthesis and Structural Analysis of Novel Bis(triazole) UDP Analogs as Potential Glycosyl Transferase Inhibitors [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1229371574

    APA Style (7th edition)

  • Knapp, Steven. Synthesis and Structural Analysis of Novel Bis(triazole) UDP Analogs as Potential Glycosyl Transferase Inhibitors. 2008. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu1229371574.

    MLA Style (8th edition)

  • Knapp, Steven. "Synthesis and Structural Analysis of Novel Bis(triazole) UDP Analogs as Potential Glycosyl Transferase Inhibitors." Master's thesis, Youngstown State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1229371574

    Chicago Manual of Style (17th edition)