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Quantitation of Ventricular Collagen in Male and Female Spontaneously Hypertensive Rats Using Hydroxyproline Analysis

Tofil, Lisa
http://rave.ohiolink.edu/etdc/view?acc_num=ysu1287946156

Abstract Details

2010, Master of Science in Biological Sciences, Youngstown State University, Department of Biological Sciences and Chemistry.
Hypertension, or chronically elevated blood pressure, can result in altered cardiac function and structure. The key structural alteration associated with hypertension is left ventricular hypertrophy. This increase in myocardial mass is based upon an increase in myocyte size and collagen deposition in the heart. Hydroxyproline, a nonessential amino acid, is found primarily in collagen. As a result, collagen content can be determined by measurement using a modification of Reddy and Enwemeka's hydroxyproline assay (1996). We tested the hypothesis that the ventricular collagen content in the hypertrophied ventricles of males is greater than in females. The results from the experiment demonstrate that there is a difference in the amount of cardiac collagen content between 18 month male and female spontaneously hypertensive rats (SHRs). The mean ± SEM for the cardiac collagen content in males was found to be 41.178 (± 11.872) µg collagen/mg weight wet ventricle (n=7) versus 30.196 (± 1.863) µg collagen/wet weight ventricle (n=7) in females.
Johanna Krontiris-Litowitz, PhD (Advisor)
Diana Fagan, PhD (Committee Member)
Gary Walker, PhD (Committee Member)
43 p.
Biology
hypertension; cardiac collagen; hydroxyproline

Recommended Citations

Citations

  • Tofil, L. (2010). Quantitation of Ventricular Collagen in Male and Female Spontaneously Hypertensive Rats Using Hydroxyproline Analysis [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1287946156

    APA Style (7th edition)

  • Tofil, Lisa. Quantitation of Ventricular Collagen in Male and Female Spontaneously Hypertensive Rats Using Hydroxyproline Analysis. 2010. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu1287946156.

    MLA Style (8th edition)

  • Tofil, Lisa. "Quantitation of Ventricular Collagen in Male and Female Spontaneously Hypertensive Rats Using Hydroxyproline Analysis." Master's thesis, Youngstown State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1287946156

    Chicago Manual of Style (17th edition)

ysu1287946156
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© 2010, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.