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Analysis of Electrokinetic Flow in Microfluidic Chips

Aryal, Sanket
http://rave.ohiolink.edu/etdc/view?acc_num=ysu1339964794

Abstract Details

2012, Master of Science in Engineering, Youngstown State University, Department of Mechanical, Industrial and Manufacturing Engineering.
Miniaturization and integration of conventional bioassay laboratory procedures into the micro-fabricated Lab-On-Chips (LOCs), usually referred to as ”Micro Total Analysis (μTAS) systems”, have tremendous impacts in the fields of genomics, proteomics, and other clinical analysis. Electrokinetically driven flow offers efficiently and effectively to control flow in micro devices without a need for any mechanical components. These bioanalytical microsystems utilize electrokinetic mobility including electroosmosis and electrophoresis modes for transport, mixing, manipulation, separation and detection of sample analytes. LOCs are already proven to significantly reduce analysis time and sample volume sizes without requiring a skilled worker to operate. In addition, LOCs are inexpensive, versatile, robust as well as portable. At the solid surfaces of the microchannel walls, an oppositely charged thin layer is formed separate from the bulk solutions of the sample analytes and buffer solutions. This thin layer is referred to as an “Electrical Double Layer (EDL)” or simply called “Debye's Thickness Layer”. Based on the type and material of the electrode surface, it is formed either by negatively or positively charged ionic groups from the bulk solution at the wall's surfaces. Using commercially available finite element software, called “COMSOL Multiphysics”, the electric field is modeled in such a way that it displaces EDL formed by ionic liquid leading to generate an electrokinetic flow in the microchannel. MEMS (Micro-electromechanical systems) and Chemical Engineering Modules of COMSOL are employed to model, physics set up, and simulate the ionic fluid flow for the analysis of fluid propulsion and chemical mass transport for the various physical models of microchips. The ionic fluid concentrations and velocities are plotted against the potential differences across the sample inlet vs. the outlet and across the buffer inlet vs. the outlet, respectively. Based on the COMSOL Multiphysics simulation results, it was concluded that the T-shaped microfluidic chip with a narrowed cross sectional area at the analysis chamber has maximum ionic velocity that increases with increase in electric potential for the EDL (Zeta potential) formed. Ionic concentration could be accumulated at the outlet by achieving higher concentrations with the electrophoresis mode. Thus, velocity and concentration distributions in the microfluidic chip could be manipulated by varying shape and size of the chips, varying potential differences between two inlets vs. outlet and varying zeta potential at the microchannel wall. In this thesis work, LOCs with microchannels were analyzed with varying parameters of electrical, chemical, and physical properties and proven their effects on the concentrations and the velocities of the sample analytes.
Yogendra Panta, PhD (Advisor)
Pedro Cortes, PhD (Committee Member)
Hans Tritico, PhD (Committee Member)
92 p.
Biomedical Engineering; Chemical Engineering; Mechanical Engineering
Electrokinetic Flow; Comsol; Electroosmosis; Microfluidics; Lab-on-chips

Recommended Citations

Citations

  • Aryal, S. (2012). Analysis of Electrokinetic Flow in Microfluidic Chips [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1339964794

    APA Style (7th edition)

  • Aryal, Sanket. Analysis of Electrokinetic Flow in Microfluidic Chips. 2012. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu1339964794.

    MLA Style (8th edition)

  • Aryal, Sanket. "Analysis of Electrokinetic Flow in Microfluidic Chips." Master's thesis, Youngstown State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1339964794

    Chicago Manual of Style (17th edition)

ysu1339964794
786
© 2012, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.