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ysu1348850012.pdf (2.13 MB)
ETD Abstract Container
Abstract Header
Click Chemistry Synthesis of Neoglycooligomers and Neoglycopolymers
Author Info
Mills, Isaac N.
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ysu1348850012
Abstract Details
Year and Degree
2012, Master of Science in Chemistry, Youngstown State University, Department of Chemistry.
Abstract
This thesis deals with the click chemistry synthesis of neoglycooligomers and the attempted click chemistry synthesis of a neoglycopolymer. Experimentation led to successful synthesis of a novel trisaccharide using a simple series of step-wise transformations starting with galactose and 1,2;3,4-di-
O
-isopropylidene-α-D-galactopyranose. Successful synthesis of the neoglycooligomer was verified using
1
H and
13
C NMR, as well as COSY, HSQC, and mass spectrometry. Experimentation also led to the synthesis of a macrocycle from 1,2;3,4-di-
O
-isopropylidene-6-
O
-prop(2-ynl)-α-D-galactopyranose, rather than the intended polymer. The macrocycle was confirmed to have formed with a distribution of four to seven monomer units using matrix-assisted laser desorption ionization (MALDI).
Committee
Peter Norris, Ph.D. (Advisor)
John Jackson, Ph.D. (Committee Member)
Nina Stourman, Ph.D. (Committee Member)
Pages
151 p.
Subject Headings
Chemistry
;
Organic Chemistry
Keywords
neoglycooligomer
;
neoglycopolymer
;
carbohydrate
;
click chemistry
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Citations
Mills, I. N. (2012).
Click Chemistry Synthesis of Neoglycooligomers and Neoglycopolymers
[Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1348850012
APA Style (7th edition)
Mills, Isaac.
Click Chemistry Synthesis of Neoglycooligomers and Neoglycopolymers.
2012. Youngstown State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ysu1348850012.
MLA Style (8th edition)
Mills, Isaac. "Click Chemistry Synthesis of Neoglycooligomers and Neoglycopolymers." Master's thesis, Youngstown State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1348850012
Chicago Manual of Style (17th edition)
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Document number:
ysu1348850012
Download Count:
511
Copyright Info
© 2012, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.