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ETD Abstract Container
Abstract Header
Improved Synthesis of Bis (2,2,2-trifluoroethyl) Phosphono Esters
Author Info
Zaluski, Jordan A
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ysu1471443290
Abstract Details
Year and Degree
2016, Master of Science in Chemistry, Youngstown State University, Department of Chemistry.
Abstract
The reaction of primary a-halo esters with potassium bis (2,2,2-trifluoroethyl) phosphite (prepared from bis (2,2,2-trifluoroethyl) phosphite, potassium hexamethyldisilazide, and 18-crown-6 in THF at -78
o
C) results in formation of the corresponding bis (2,2,2-trifluoroethyl) phosphono esters in good yield (60-74%). Yields diminish significantly when secondary α-halo esters are employed (10-12%) due to steric factors. Reaction conditions were applied to primary alkyl halides and α-halo ketones for the synthesis of bis (2,2,2-trifluoroethyl) alkyl phosphonates and bis (2,2,2-trifluoroethyl) vinyl phosphates respectively.
Committee
John Jackson, PhD (Advisor)
Douglas Genna, PhD (Committee Member)
Brian Leskiw, PhD (Committee Member)
Pages
111 p.
Subject Headings
Chemistry
Keywords
2,2,2-trifluoroethyl
;
phosphono esters
;
phosphonates
;
vinyl phosphates
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Citations
Zaluski, J. A. (2016).
Improved Synthesis of Bis (2,2,2-trifluoroethyl) Phosphono Esters
[Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1471443290
APA Style (7th edition)
Zaluski, Jordan.
Improved Synthesis of Bis (2,2,2-trifluoroethyl) Phosphono Esters.
2016. Youngstown State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ysu1471443290.
MLA Style (8th edition)
Zaluski, Jordan. "Improved Synthesis of Bis (2,2,2-trifluoroethyl) Phosphono Esters." Master's thesis, Youngstown State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1471443290
Chicago Manual of Style (17th edition)
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Document number:
ysu1471443290
Download Count:
843
Copyright Info
© 2016, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.