Skip to Main Content
 

Global Search Box

 
 
 
 

ETD Abstract Container

Abstract Header

Towards the Synthesis of Novel Glycomimetics of N-Acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (D-ManNAcA) and Derivatives

Buabeng, Emmnauel Ramsey

Abstract Details

2016, Master of Science in Chemistry, Youngstown State University, Department of Chemistry.
An efficient synthetic scheme has been employed for the synthesis of glycomimetics of N-acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (DManNAcA) and derivatives from easily available D-glucuronolactone in 33-100% yields. These glycomimetics could be tested for possible inhibition of the enzymes responsible for the biosynthesis of the capsular polysaccharides found in Staphylococcus aureus. These microcapsules are antiphagocytic enabling these invasive pathogens to exist in the blood stream multiplying and destroying host cells. The aim of this work is to develop glycomimetics of D-ManNAcA (below) that may act as potential inhibitors of the enzyme transferase.
Peter Norris, PhD (Advisor)
John Jackson, PhD (Committee Member)
Nina Stourman, PhD (Committee Member)
110 p.

Recommended Citations

Citations

  • Buabeng, E. R. (2016). Towards the Synthesis of Novel Glycomimetics of N-Acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (D-ManNAcA) and Derivatives [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1471478050

    APA Style (7th edition)

  • Buabeng, Emmnauel. Towards the Synthesis of Novel Glycomimetics of N-Acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (D-ManNAcA) and Derivatives. 2016. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu1471478050.

    MLA Style (8th edition)

  • Buabeng, Emmnauel. "Towards the Synthesis of Novel Glycomimetics of N-Acetyl-2-amino-2-deoxy-D-mannopyranose uronic acid (D-ManNAcA) and Derivatives." Master's thesis, Youngstown State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1471478050

    Chicago Manual of Style (17th edition)