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A Biomechanical Investigation of Collagen, Platelet-rich Plasma, and Mesenchymal Stromal Cells on the Achilles Tendon in a Rat Model

Austin, Brittany Logan
http://orcid.org/0000-0003-0462-3777
http://rave.ohiolink.edu/etdc/view?acc_num=ysu155905140840335

Abstract Details

2019, Master of Science in Engineering, Youngstown State University, Department of Mechanical, Industrial and Manufacturing Engineering.
It is estimated that about 18 out of 100,000 people rupture their Achilles tendon every year. A review of 4000 Achilles tendon ruptures found that 75% were related to sports activities. Currently, the methods for fixing Achilles tendon ruptures are in need of improvement. Due to the prevalence of Achilles tendon injuries in sports and the fact that tendons have poor wound healing, there has been an abundance of studies on treatments for Achilles tendon injuries. Many different techniques and therapies using biologics have been researched. One area, however, that has not been well researched is the addition of a combination of mesenchymal stromal cells and platelet-rich plasma as a treatment method for wound healing enhancement. There is also a lack of studies comparing different treatment methods as they progress through time. This study chose the following treatment methods: collagen (CoTa); collagen and platelet-rich plasma (PRP); collagen and mesenchymal stromal cells (MSC); and collagen, platelet-rich plasma, and mesenchymal stromal cells (CPM) to follow through two recovery times: 1 week and 2 weeks. Lewis rats were chosen and a full transection of the right Achilles tendon was performed 6 mm proximal to the calcaneal bone. At 1 or 2 weeks both Achilles tendons of the rats were extracted and tensile tests were performed. Maximum force, engineering stress, strain, modulus of elasticity, total strain energy, and elastic strain energy were determined. Differences in the treatment groups at 1 week recovery were notable, no differences were found between the treatment groups at 2 week recovery, however differences could be seen when compared to the left virgin tissue controls. Computational modeling led to preliminary finite element models for each treatment group. Validation for each model was achieved by comparison with experimental data. Further development of the finite element analysis would allow for a more accurate model and allow for better comparisons between treatment groups.
Hazel Marie, PhD (Advisor)
Diana Fagan, PhD (Committee Member)
Virgil Solomon, PhD (Committee Member)
Jason Walker, PhD (Committee Member)
143 p.
Biomechanics; Biomedical Engineering; Biomedical Research
biomedical; Achilles; tendon; biomechanical testing; mesenchymal stromal cells; platelet-rich plasma; biologics

Recommended Citations

Citations

  • Austin, B. L. (2019). A Biomechanical Investigation of Collagen, Platelet-rich Plasma, and Mesenchymal Stromal Cells on the Achilles Tendon in a Rat Model [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu155905140840335

    APA Style (7th edition)

  • Austin, Brittany. A Biomechanical Investigation of Collagen, Platelet-rich Plasma, and Mesenchymal Stromal Cells on the Achilles Tendon in a Rat Model. 2019. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu155905140840335.

    MLA Style (8th edition)

  • Austin, Brittany. "A Biomechanical Investigation of Collagen, Platelet-rich Plasma, and Mesenchymal Stromal Cells on the Achilles Tendon in a Rat Model." Master's thesis, Youngstown State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ysu155905140840335

    Chicago Manual of Style (17th edition)

ysu155905140840335
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This open access ETD is published by Youngstown State University and OhioLINK.