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Drug Discovery: identification of Anticancer Properties of Podophyllotoxin Analogues

Huffman, Olivia G
http://rave.ohiolink.edu/etdc/view?acc_num=ysu1588874335556129

Abstract Details

2020, Master of Science in Biological Sciences, Youngstown State University, Department of Biological Sciences and Chemistry.
The purpose of this research involves the study of plant compound podophyllotoxin and the potential benefits of podophyllotoxin analogues on cancer therapy. Podophyllotoxin has been found to have anticancer properties due to its role in tubulin depolymerization within the cell cycle. Cancer is a growing concern throughout the United States and across the world. The most well-known cancer therapies are synthetic in nature and can be very harmful to the body, leaving the growing need for natural product plant-derived anticancer therapies. In this study, the potential anticancer properties of structural analogues of podophyllotoxin will be evaluated for their effects on cell viability, apoptosis induction, cell-cycle control, and migration. Podophyllotoxin analogues will be screened using cell lines A549, MCF7, MDA-MB-231, SK-MEL-28, and Jurkat, with the aims of discovering more potent compounds.
Gary Walker, PhD (Advisor)
Séverine Van slambrouck, PhD (Committee Member)
Wim Steelant, PhD (Committee Member)
58 p.
Biochemistry; Biology; Oncology; Pathology; Pharmaceuticals; Toxicology
cancer; oncology; podophyllotoxin; natural products; biochemistry; phytochemicals; anticancer drug discovery

Recommended Citations

Citations

  • Huffman, O. G. (2020). Drug Discovery: identification of Anticancer Properties of Podophyllotoxin Analogues [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1588874335556129

    APA Style (7th edition)

  • Huffman, Olivia. Drug Discovery: identification of Anticancer Properties of Podophyllotoxin Analogues. 2020. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu1588874335556129.

    MLA Style (8th edition)

  • Huffman, Olivia. "Drug Discovery: identification of Anticancer Properties of Podophyllotoxin Analogues." Master's thesis, Youngstown State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1588874335556129

    Chicago Manual of Style (17th edition)

ysu1588874335556129
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© 2020, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.