Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


ysu997203042.pdf (4.29 MB)

ETD Abstract Container

Abstract Header

Estrogen modulation of MPP + - induced Dopamine secretion in the Corpus Striatum and Nucleus accumbens of the Rat Brain

Arvin, Michael, Jr.
http://rave.ohiolink.edu/etdc/view?acc_num=ysu997203042

Abstract Details

1998, Master of Science in Biological Sciences, Youngstown State University, Department of Biological Sciences and Chemistry.
Parkinson’s disease, first described in 1817, is a progressive disorder affecting men and women of middle age and older. The disease results in a disruption of normal motor function. Classic features include muscle rigidity, resting tremor, and the inability to initiate normal muscle movement. These symptoms are the result of the destruction of dopamine producing neurons in an area of the brain known as the Substantia Nigra and the subsequent depletion of dopamine in the striatum. The cause of the disorder is still unknown. Possible contributing factors proposed include environmentally acquired toxins, and/or endogenous toxic metabolic byproducts. There is also the possibility of a genetic component predisposing certain individuals to the disorder. This study was designed to investigate the modulatory and possible neuroprotective effects of the steroid hormone estrogen upon dopamine release and clearance from neurons of the nigrostriatal system. An in vivo animal model, along with the technique of in vivo electrochemistry was used to demonstrate, in real time, the characteristics of dopamine release and clearance. This is accomplished through the use of a stereotaxic instrument which allows for the placement of an electrode and micropipette assemble into specific brain regions. A neurotoxin, MPP -1 , which stimulates the biochemical events seen in Parkinson’s disease was used to stimulate the release of dopamine from the nigrostriatal neurons. Female ovarectomized rats were divided into two treatment groups, MPP + alone, and MPP + with estrogen. These treatments were applied to the rat forebrain and measurement of the ensuing dopamine release were monitored using the IVEC-10 system and software capable of measuring neurochemical substances such as dopamine. Results of this study demonstrate a modulatory and/or neuroprotective effect of estrogen upon neurons of the nigrostriatal pathway by decreasing the effectiveness of MPP + to elicit the release of dopamine from these neurons. The results of this study also reveal differences, in some release and clearance parameters, between the corpus striatum and nucleus accumbens.
Robert Leipheimer (Advisor)
159 p.
Biology, General
Parkinson's Disease; dopamine; MPP +; nucleus accumbens

Recommended Citations

Citations

  • Arvin, Jr., M. (1998). Estrogen modulation of MPP + - induced Dopamine secretion in the Corpus Striatum and Nucleus accumbens of the Rat Brain [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu997203042

    APA Style (7th edition)

  • Arvin, Jr., Michael. Estrogen modulation of MPP + - induced Dopamine secretion in the Corpus Striatum and Nucleus accumbens of the Rat Brain. 1998. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu997203042.

    MLA Style (8th edition)

  • Arvin, Jr., Michael. "Estrogen modulation of MPP + - induced Dopamine secretion in the Corpus Striatum and Nucleus accumbens of the Rat Brain." Master's thesis, Youngstown State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=ysu997203042

    Chicago Manual of Style (17th edition)

ysu997203042
764
© 1998, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.