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Effect of Nitric Oxide Reagents on Intracellular Calcium Signaling in RBL-2H3 Mucosal Mast Cells

Cutrone, Rochelle Marie
http://rave.ohiolink.edu/etdc/view?acc_num=ysu998684385

Abstract Details

2001, Master of Science in Chemistry, Youngstown State University, Department of Chemistry.
Evidence has shown that intracellular calcium must be elevated in order for secretion of the granular contents within mast cells to occur. Exegenous nitric oxide (NO) has the effect of dampening the secretory responses of mast cells while the inhibition of nitric oxide synthase (NOS) amplifies the secretion. As elevation of intracellular calcium concentration is essential for secretion to occur, it is likely that NO inhibits secretion by activating calcium pumps leading to the removal of calcium from the cytosol. This research examines the role of nitric oxide in the regulation of antigen-activated RBL-2H3 mucosal mast cells and looks to determine which parts of the signal transduction pathway are involved in the activation and regulation of NO biosynthesis. Knowing that the NO-producing enzyme, nitric oxide synthase (NOS), is regulated by intracellular calcium, we will investigate whether a change in nitric oxide production affects intracellular calcium signals.
Thomas Kim (Advisor)
51 p.
Chemistry, General
intracellular calcium

Recommended Citations

Citations

  • Cutrone, R. M. (2001). Effect of Nitric Oxide Reagents on Intracellular Calcium Signaling in RBL-2H3 Mucosal Mast Cells [Master's thesis, Youngstown State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ysu998684385

    APA Style (7th edition)

  • Cutrone, Rochelle. Effect of Nitric Oxide Reagents on Intracellular Calcium Signaling in RBL-2H3 Mucosal Mast Cells. 2001. Youngstown State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ysu998684385.

    MLA Style (8th edition)

  • Cutrone, Rochelle. "Effect of Nitric Oxide Reagents on Intracellular Calcium Signaling in RBL-2H3 Mucosal Mast Cells." Master's thesis, Youngstown State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ysu998684385

    Chicago Manual of Style (17th edition)

ysu998684385
525
© 2001, all rights reserved.
This open access ETD is published by Youngstown State University and OhioLINK.