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A MITRAL VALVE PROLAPSE STUDY USING ELECTRICALLY INDUCED ARRHYTHMIA WITH NOREPINEPHRINE ADMINISTRATION TO PRODUCE PROLAPSING IN SHR AND WKY FEMALE RATS

Langworthy, Annissa R
http://rave.ohiolink.edu/etdc/view?acc_num=akron1155045566

Abstract Details

2006, Master of Science, University of Akron, Biology.
Mitral valve prolapse (MVP) effects 5 -15%of the world’s population, it is the most common form of heart valve abnormality diagnosed in females, and shows a decrease in cardiac output and aortic distensibility. Hypertension is the number one most diagnosed cardiovascular disease in the United States, and has been observed to exacerbate and/or coincide with other existing diseases, also showing a decreasing cardiac output and aortic distensibility. The hypothesis for this project was: Hypertension increases the severity of mitral valve prolapse and its associated symptoms in female SHR rats compared to WKY female rats. WKY and SHR female rats that were older than 12 weeks were separated into 4 groups; the assigned groups were: WKY control (WKY CTL), WKY experimental (WKY EXP), SHR-control (SHR CTL), and SHR experimental (SHR EXP). Each rat was fitted with a Doppler probe to monitor flow velocity in the abdominal aorta to compare cardiac performance. Blood pressure, EKG and flow velocities were measured weekly for five weeks. Results showed that the SHR EXP had highest means where there was significance for treatment level (baseline vs. post treatment) for cardiac output, epinephrine and tissue damage. For cardiac output (F=5.693, p=0.027), for epinephrine (F=43.985, p<0.001), for tissue damage (F=4.834, p=0.040). For norepinephrine there was statistical difference among the different levels of treatment (baseline vs. posttreatment) F=5.279, p=0.032 (SHR CTL had highest mean). These results suggest the catecholamine levels could be due to sympathetic dysfunction being more impaired in SHR EXP group, causing the decrease of norepinephrine and increase of epinephrine. This type of catecholamine response would drive up the cardiac output in the SHR EXP group. This data combined with the SHR EXP group having the most ventricle damage indicates heart failure initiating. In conclusion, hypertension is associated with the severity of symptoms for mitral valve prolapse.
Daniel Ely (Advisor)
Mitral valve prolapse; hypertension; norepinephrine; SHR; WKY; Spontaneously hypertensive rat; arrythmia; ventricular tachycardia; sympathetic nervous system malfunction

Recommended Citations

Citations

  • Langworthy, A. R. (2006). A MITRAL VALVE PROLAPSE STUDY USING ELECTRICALLY INDUCED ARRHYTHMIA WITH NOREPINEPHRINE ADMINISTRATION TO PRODUCE PROLAPSING IN SHR AND WKY FEMALE RATS [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1155045566

    APA Style (7th edition)

  • Langworthy, Annissa. A MITRAL VALVE PROLAPSE STUDY USING ELECTRICALLY INDUCED ARRHYTHMIA WITH NOREPINEPHRINE ADMINISTRATION TO PRODUCE PROLAPSING IN SHR AND WKY FEMALE RATS. 2006. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1155045566.

    MLA Style (8th edition)

  • Langworthy, Annissa. "A MITRAL VALVE PROLAPSE STUDY USING ELECTRICALLY INDUCED ARRHYTHMIA WITH NOREPINEPHRINE ADMINISTRATION TO PRODUCE PROLAPSING IN SHR AND WKY FEMALE RATS." Master's thesis, University of Akron, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=akron1155045566

    Chicago Manual of Style (17th edition)

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This open access ETD is published by University of Akron and OhioLINK.