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EFFECTS OF ANTIOXIDANT ON CARDIOVASCULAR PERFORMANCE, EXERCISE CAPACITY, AND FUNCTIONAL STATUS IN PATIENTS WITH CHRONIC HEART FAILURE

Ho, Chao-Chung

Abstract Details

2007, Doctor of Philosophy, Case Western Reserve University, Nursing.
Purpose To evaluate the effects of antioxidant on cardiovascular performance, exercise capacity and health status in chronic heart failure patients. Methods This was a cross-over, randomized controlled trial. A total of 37 subjects were allocated to two groups randomly. Group I (n = 19) received vitamin C 4000 mg daily for 4 weeks and followed by placebo for 6 weeks. Group II (n = 18) received placebo for 6 weeks and followed by vitamin C 4000 mg daily for 4 weeks. The tumor necrosis factor-alpha (TNF-á) was examined as an indicator of inflammatory process. The endothelial function was measured by flow-mediated vasodilation. The cardiac performance was measure by left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF). Exercise capacity was evaluated by the total distance of six-minute walk test (6MWT). The functional status was assessed by three questionnaires, the Medical Outcomes Study Short Form 36-item Survey (SF-36), the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and the Center Epidemiologic study for Depression questionnaire (CES-D). Results There was a statistic difference in brachial diameter change percentage, baseline flow, and peak flow while using antioxidant supplementation compared to when they not using antioxidant supplementation (F = 10.97, 16.17, 8.57, p < .001, < .001, = .001, respectively). There was no significant difference in LVEDD (F = .31, p = .692). However, there was a significant difference in LVEF while using antioxidant supplementation (F = 35.60, p < .001). There was a statistical increase in 6MWT while using antioxidant supplementation (F = 40.84, p < .001,). There was a statistic difference in the SF-36, the MLHFQ, and the CES-D while using antioxidant supplementation compared to when they not using antioxidant supplementation (F = 5.91, 19.53, 24.47, p = .009, < .001, < .001, respectively). Conclusions This study provided an evidence-base of identifying the effects of vitamin C on mitigating the pro-inflammatory process, improving endothelial function, improving the cardiac contractility, augmenting exercise capacity, promoting the quality of life, and alleviating the depressive symptoms in patients with chronic heart failure.
John Clochesy (Advisor)
216 p.

Recommended Citations

Citations

  • Ho, C.-C. (2007). EFFECTS OF ANTIOXIDANT ON CARDIOVASCULAR PERFORMANCE, EXERCISE CAPACITY, AND FUNCTIONAL STATUS IN PATIENTS WITH CHRONIC HEART FAILURE [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1157980994

    APA Style (7th edition)

  • Ho, Chao-Chung. EFFECTS OF ANTIOXIDANT ON CARDIOVASCULAR PERFORMANCE, EXERCISE CAPACITY, AND FUNCTIONAL STATUS IN PATIENTS WITH CHRONIC HEART FAILURE. 2007. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1157980994.

    MLA Style (8th edition)

  • Ho, Chao-Chung. "EFFECTS OF ANTIOXIDANT ON CARDIOVASCULAR PERFORMANCE, EXERCISE CAPACITY, AND FUNCTIONAL STATUS IN PATIENTS WITH CHRONIC HEART FAILURE." Doctoral dissertation, Case Western Reserve University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1157980994

    Chicago Manual of Style (17th edition)