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The Role of IFRD1 during the Integrated Stress Response

Ndum, Ogechukwu S.
http://rave.ohiolink.edu/etdc/view?acc_num=case1270751192

Abstract Details

2010, Master of Sciences, Case Western Reserve University, Pathology.
This study focuses on a gene, IFRD1. We believe that IFRD1 is a stress responsive gene that is tightly regulated by eIF2 alpha and may play a key role in cell behavior during the integrated stress response. IFRD1 has not been previously identified as a stress responsive gene, however, preliminary evidence demonstrates that IFRD1 expression is elevated by stress inducing agent, Tunicamycin, and the induction of IFRD1 expression is mediated through eIF2 alpha. In addition, preliminary experiments conducted in dextran sodium sulfate induced colitis mouse models show that IFRD1 deficient mice suffered significantly more colonic tissue damage compared to the wildtype mice, suggesting that IFRD1 may play a role in determining cell fate in response to stress. The goal of this study is to further analyze the regulation of IFRD1 during cellular stress and to begin to understand the role that IFRD1 plays in protecting the cells during stress.
Thomas Hamilton, PhD (Advisor)
George Dubyak, PhD (Committee Chair)
Eric Pearlman, PhD (Committee Member)
Xiaoxia Li, PhD (Committee Member)
Clive Hamlin, PhD (Committee Member)
69 p.
Molecular Biology
IFRD1; integrated stress response. eIF2 alpha; GCN2

Recommended Citations

Citations

  • Ndum, O. S. (2010). The Role of IFRD1 during the Integrated Stress Response [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1270751192

    APA Style (7th edition)

  • Ndum, Ogechukwu. The Role of IFRD1 during the Integrated Stress Response. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1270751192.

    MLA Style (8th edition)

  • Ndum, Ogechukwu. "The Role of IFRD1 during the Integrated Stress Response." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1270751192

    Chicago Manual of Style (17th edition)

case1270751192
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© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.