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Development and Commercialization of Remyelination Therapeutics to Restore Neural Function in Multiple Sclerosis

Padam, Amith Chordia
http://rave.ohiolink.edu/etdc/view?acc_num=case1304690351

Abstract Details

2011, Master of Sciences, Case Western Reserve University, Biology.
Multiple sclerosis (MS) affects around 400,000 people in the United States and above 2.5 million individuals throughout the world. There is currently no cure for MS, but the currently marketed anti-inflammatory drugs developed to combat MS are partially effective in delaying the disease. Although the exact cause of MS is not known, the onset is characterized by infiltration of immune cells and the destruction of oligodendrocytes and myelin leading to loss of neural function. Based on years of research in the laboratories of Drs. Trapp & Macklin, Renovo Neural’s approach is to use small molecules that can therapeutically stimulate oligodendrocyte differentiation eventually enhancing remyelination. The thesis will focus on Renovo Neural’s approach to develop compounds that stimulate remyelination, development plan and exit strategy.
Roy Ritzmann (Committee Chair)
Christopher Cullis (Advisor)
James Zull (Committee Member)
Satish Medicetty (Committee Member)
65 p.
Biology; Health Sciences; Hispanic Americans; Neurobiology; Neurosciences; Pharmaceuticals
Multiple sclerosis; remyelination; demyelination; myelin; oligodendrocyte; oligodendrocyte precursor cells; OPC differentiation;

Recommended Citations

Citations

  • Padam, A. C. (2011). Development and Commercialization of Remyelination Therapeutics to Restore Neural Function in Multiple Sclerosis [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1304690351

    APA Style (7th edition)

  • Padam, Amith Chordia. Development and Commercialization of Remyelination Therapeutics to Restore Neural Function in Multiple Sclerosis. 2011. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1304690351.

    MLA Style (8th edition)

  • Padam, Amith Chordia. "Development and Commercialization of Remyelination Therapeutics to Restore Neural Function in Multiple Sclerosis." Master's thesis, Case Western Reserve University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1304690351

    Chicago Manual of Style (17th edition)

case1304690351
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© 2011, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.