Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


Wenbo Chen.pdf (9.18 MB)

ETD Abstract Container

Abstract Header

Identification and Characterization of Small Molecules that Modulate Hair Cell Development and Regeneration in the Zebrafish Lateral Line System

Chen, Wenbo
http://orcid.org/0000-0002-4145-5445
http://rave.ohiolink.edu/etdc/view?acc_num=case1427992116

Abstract Details

2015, Master of Sciences, Case Western Reserve University, Biology.
Hair cells, mechanoreceptors in the ear, initiate the perception of sound. It has been demonstrated that loss of hair cells is a key factor in sensorineural hearing loss, for which there is no cure. With the ultimate goal to reverse hearing loss at the level of hair cells, 5040 chemicals from a novel compound library were evaluated for their potential modulatory effect on hair cell development and regeneration, using zebrafish lateral line neuromasts. Three enhancers and six inhibitors were confirmed by subsequent dose-response analysis. In addition, I determined that LY-411575 induced hair cell formation in zebrafish but the hair bundles were severely misorientated. Moreover, a critical window was demonstrated to be particularly important for maintaining planar cell polarity during the LY-411575 mediated hair cell regeneration process. Collectively, this research provides insight into the characterization of potential hair cell modulators.
Brian McDermott, Jr. (Advisor)
91 p.
Biology

Recommended Citations

Citations

  • Chen, W. (2015). Identification and Characterization of Small Molecules that Modulate Hair Cell Development and Regeneration in the Zebrafish Lateral Line System [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1427992116

    APA Style (7th edition)

  • Chen, Wenbo. Identification and Characterization of Small Molecules that Modulate Hair Cell Development and Regeneration in the Zebrafish Lateral Line System. 2015. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1427992116.

    MLA Style (8th edition)

  • Chen, Wenbo. "Identification and Characterization of Small Molecules that Modulate Hair Cell Development and Regeneration in the Zebrafish Lateral Line System." Master's thesis, Case Western Reserve University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1427992116

    Chicago Manual of Style (17th edition)

case1427992116
911
© 2015, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.