Skip to Main Content
 

Global Search Box

 
 
 
 

ETD Abstract Container

Abstract Header

Altered adult neurogenesis in a mouse model of human tauopathy

Komuro, Yutaro

Abstract Details

2015, Doctor of Philosophy, Case Western Reserve University, Molecular Medicine.
Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, characterized by progressive cognitive decline and widespread brain atrophy following hyperphosphorylation and aggregation of microtubule-associated protein tau (MAPT). Presently, there is no treatment, and the underlying source of pathogenesis has not been identified. One of the symptoms commonly found in tauopathies is a reduction in neurogenesis, the birth of new neurons. However, the relation between neurogenesis and MAPT has never been examined. In these studies, we used a mouse model of human tauopathy known as the hTau mouse, which expresses human MAPT and develops an age-related tauopathy, to examine adult neurogenesis. Our characterization of adult neurogenesis in the hTau mouse found that hTau mice exhibit reduced neurogenesis as early as 2 months of age, a substantially earlier marker than previously described pathology in the model. This alteration was found to be due to reduced proliferation and correlated with increased MAPT phosphorylation in the neurogenic precursors. Neurospheres grown in vitro further revealed an inherent proliferative defect. These findings suggest that altered adult neurogenesis is a strong early marker of alterations in MAPT in the hTau mouse model of tauopathy, and that further research should be conducted in examining adult neurogenesis as a marker and therapeutic target for human tauopathies.
Bruce Lamb (Advisor)
Gary Landreth (Committee Chair)
Sanjay Pimplikar (Committee Member)
Alexander Rae-Grant (Committee Member)
Thomas Egelhoff (Committee Member)
102 p.

Recommended Citations

Citations

  • Komuro, Y. (2015). Altered adult neurogenesis in a mouse model of human tauopathy [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1434743393

    APA Style (7th edition)

  • Komuro, Yutaro. Altered adult neurogenesis in a mouse model of human tauopathy. 2015. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1434743393.

    MLA Style (8th edition)

  • Komuro, Yutaro. "Altered adult neurogenesis in a mouse model of human tauopathy." Doctoral dissertation, Case Western Reserve University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1434743393

    Chicago Manual of Style (17th edition)