Skip to Main Content
Frequently Asked Questions
Submit an ETD
Global Search Box
Need Help?
Keyword Search
Participating Institutions
Advanced Search
School Logo
Files
File List
Yutaro Komuro Revised Dissertation.pdf (1.01 MB)
ETD Abstract Container
Abstract Header
Altered adult neurogenesis in a mouse model of human tauopathy
Author Info
Komuro, Yutaro
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=case1434743393
Abstract Details
Year and Degree
2015, Doctor of Philosophy, Case Western Reserve University, Molecular Medicine.
Abstract
Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, characterized by progressive cognitive decline and widespread brain atrophy following hyperphosphorylation and aggregation of microtubule-associated protein tau (MAPT). Presently, there is no treatment, and the underlying source of pathogenesis has not been identified. One of the symptoms commonly found in tauopathies is a reduction in neurogenesis, the birth of new neurons. However, the relation between neurogenesis and MAPT has never been examined. In these studies, we used a mouse model of human tauopathy known as the hTau mouse, which expresses human MAPT and develops an age-related tauopathy, to examine adult neurogenesis. Our characterization of adult neurogenesis in the hTau mouse found that hTau mice exhibit reduced neurogenesis as early as 2 months of age, a substantially earlier marker than previously described pathology in the model. This alteration was found to be due to reduced proliferation and correlated with increased MAPT phosphorylation in the neurogenic precursors. Neurospheres grown in vitro further revealed an inherent proliferative defect. These findings suggest that altered adult neurogenesis is a strong early marker of alterations in MAPT in the hTau mouse model of tauopathy, and that further research should be conducted in examining adult neurogenesis as a marker and therapeutic target for human tauopathies.
Committee
Bruce Lamb (Advisor)
Gary Landreth (Committee Chair)
Sanjay Pimplikar (Committee Member)
Alexander Rae-Grant (Committee Member)
Thomas Egelhoff (Committee Member)
Pages
102 p.
Subject Headings
Biology
;
Biomedical Research
Keywords
neurogenesis
;
Alzheimers disease
;
tauopathy
;
tau protein
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
Komuro, Y. (2015).
Altered adult neurogenesis in a mouse model of human tauopathy
[Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1434743393
APA Style (7th edition)
Komuro, Yutaro.
Altered adult neurogenesis in a mouse model of human tauopathy.
2015. Case Western Reserve University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=case1434743393.
MLA Style (8th edition)
Komuro, Yutaro. "Altered adult neurogenesis in a mouse model of human tauopathy." Doctoral dissertation, Case Western Reserve University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1434743393
Chicago Manual of Style (17th edition)
Abstract Footer
Document number:
case1434743393
Download Count:
621
Copyright Info
© 2015, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.