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Audrey Lord - MS Thesis - 4-21-22.pdf (1.57 MB)

ETD Abstract Container

Abstract Header

The Role of Fabrication Parameters on Release of Anti-Inflammatory Agents from Silicone Medical Devices

Lord, Audrey E
http://rave.ohiolink.edu/etdc/view?acc_num=case1650539505001585

Abstract Details

2022, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Medical device implantation inevitably invokes an inflammatory response by the body. While this response is necessary to the healing process, its persistence can impair device function. To modulate this response, anti-inflammatory agents are often administered, though side effects limit their benefit. Silicone is a biocompatible material widely used in medical devices and its fabrication parameters are investigated here toward better understanding of how this material may be leveraged for local drug delivery. Crosslinking density, drug loading method, and polymer curing are assessed through release of three anti-inflammatory agents: lenalidomide, dexamethasone, and curcumin. Demonstrated here is the use of silicone as a coating applied to stainless steel, with up to two months of anti-inflammatory release. The parameters evaluated serve to inform the development of drug delivery systems using silicone. Further, the silicone steel coating presented demonstrates promise for simple alterations of current devices to protect patients and device function.
Horst von Recum (Advisor)
James Anderson (Committee Member)
Andrew Shoffstall (Committee Member)
43 p.
Biomedical Engineering
drug delivery; silicone; PDMS; anti-inflammatory; foreign body reaction

Recommended Citations

Citations

  • Lord, A. E. (2022). The Role of Fabrication Parameters on Release of Anti-Inflammatory Agents from Silicone Medical Devices [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1650539505001585

    APA Style (7th edition)

  • Lord, Audrey. The Role of Fabrication Parameters on Release of Anti-Inflammatory Agents from Silicone Medical Devices. 2022. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1650539505001585.

    MLA Style (8th edition)

  • Lord, Audrey. "The Role of Fabrication Parameters on Release of Anti-Inflammatory Agents from Silicone Medical Devices." Master's thesis, Case Western Reserve University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=case1650539505001585

    Chicago Manual of Style (17th edition)

case1650539505001585
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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.